The voltage-gated KCNQ1 (KvLQT1, Kv7.1) potassium channel plays a crucial role in shaping
the cardiac action potential as well as in controlling the water and salt homeostasis in …

About 10 distinct potassium channels in the heart are involved in shaping the action potential.
Some of the K + channels are primarily responsible for early repolarization, whereas …

The large conductance calcium- and voltage-activated K + channel (KCa1.1, BK, MaxiK) is
ubiquitously expressed in the body, and holds the ability to integrate changes in intracellular …

At present, transgenes in Caenorhabditis elegans are generated by injecting DNA into the
germline. The DNA assembles into a semistable extrachromosomal array composed of many …

Congenital long QT syndrome (LQTS) is a hereditary disorder that leads to sudden cardiac
death secondary to fatal cardiac arrhythmias. Although many genes for LQTS have been …

Background— Recently, evidence has emerged that small-conductance Ca 2+ -activated K
+ (SK) channels are predominantly expressed in the atria in a number of species including …

Aims Small-conductance calcium-activated potassium (SK) channels are expressed in the
heart of various species, including humans. The aim of the present study was to address …

KCNE4 is a membrane protein belonging to a family of single transmembrane domain proteins
known to have dramatic effect on the gating of certain potassium channels. However, no …

Background— Recent evidence points to functional Ca 2+ -dependent K + (SK) channels in
the heart that may govern atrial fibrillation (AF) risk, but the underlying mechanisms are …

The function of the KCNE5 (KCNE1-like) protein has not previously been described. Here
we show that KCNE5 induces both a time- and voltage-dependent modulation of the KCNQ1 …