The KCNQ1 potassium channel: from gene to physiological function
T Jespersen, M Grunnet, SP Olesen - Physiology, 2005 - journals.physiology.org
The voltage-gated KCNQ1 (KvLQT1, Kv7.1) potassium channel plays a crucial role in shaping
the cardiac action potential as well as in controlling the water and salt homeostasis in …
the cardiac action potential as well as in controlling the water and salt homeostasis in …
Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia
About 10 distinct potassium channels in the heart are involved in shaping the action potential.
Some of the K + channels are primarily responsible for early repolarization, whereas …
Some of the K + channels are primarily responsible for early repolarization, whereas …
[HTML][HTML] BK channel activators and their therapeutic perspectives
…, SP Olesen, LCB Rønn, M Grunnet - Frontiers in …, 2014 - frontiersin.org
The large conductance calcium- and voltage-activated K + channel (KCa1.1, BK, MaxiK) is
ubiquitously expressed in the body, and holds the ability to integrate changes in intracellular …
ubiquitously expressed in the body, and holds the ability to integrate changes in intracellular …
Single-copy insertion of transgenes in Caenorhabditis elegans
…, BJ Newman, JM Thummel, SP Olesen, M Grunnet… - Nature …, 2008 - nature.com
At present, transgenes in Caenorhabditis elegans are generated by injecting DNA into the
germline. The DNA assembles into a semistable extrachromosomal array composed of many …
germline. The DNA assembles into a semistable extrachromosomal array composed of many …
[PDF][PDF] Identification of a Kir3. 4 mutation in congenital long QT syndrome
Y Yang, Y Yang, B Liang, J Liu, J Li, M Grunnet… - The American Journal of …, 2010 - cell.com
Congenital long QT syndrome (LQTS) is a hereditary disorder that leads to sudden cardiac
death secondary to fatal cardiac arrhythmias. Although many genes for LQTS have been …
death secondary to fatal cardiac arrhythmias. Although many genes for LQTS have been …
Inhibition of Small-Conductance Ca2+-Activated K+ Channels Terminates and Protects Against Atrial Fibrillation
…, B Al-Shahib, T Jespersen, M Grunnet… - Circulation …, 2010 - Am Heart Assoc
Background— Recently, evidence has emerged that small-conductance Ca 2+ -activated K
+ (SK) channels are predominantly expressed in the atria in a number of species including …
+ (SK) channels are predominantly expressed in the atria in a number of species including …
Small-conductance calcium-activated potassium (SK) channels contribute to action potential repolarization in human atria
…, E Wettwer, U Ravens, M Grunnet… - Cardiovascular …, 2014 - academic.oup.com
Aims Small-conductance calcium-activated potassium (SK) channels are expressed in the
heart of various species, including humans. The aim of the present study was to address …
heart of various species, including humans. The aim of the present study was to address …
KCNE4 is an inhibitory subunit to the KCNQ1 channel
M Grunnet, T Jespersen, HB Rasmussen… - The Journal of …, 2002 - Wiley Online Library
KCNE4 is a membrane protein belonging to a family of single transmembrane domain proteins
known to have dramatic effect on the gating of certain potassium channels. However, no …
known to have dramatic effect on the gating of certain potassium channels. However, no …
Role of small-conductance calcium-activated potassium channels in atrial electrophysiology and fibrillation in the dog
…, H Huang, M Harada, M Aflaki, D Dobrev, M Grunnet… - Circulation, 2014 - Am Heart Assoc
Background— Recent evidence points to functional Ca 2+ -dependent K + (SK) channels in
the heart that may govern atrial fibrillation (AF) risk, but the underlying mechanisms are …
the heart that may govern atrial fibrillation (AF) risk, but the underlying mechanisms are …
[HTML][HTML] KCNE5 induces time-and voltage-dependent modulation of the KCNQ1 current
K Angelo, T Jespersen, M Grunnet, MS Nielsen… - Biophysical journal, 2002 - cell.com
The function of the KCNE5 (KCNE1-like) protein has not previously been described. Here
we show that KCNE5 induces both a time- and voltage-dependent modulation of the KCNQ1 …
we show that KCNE5 induces both a time- and voltage-dependent modulation of the KCNQ1 …