[HTML][HTML] Activation-independent parathyroid hormone receptor internalization is regulated by NHERF1 (EBP50)

…, CA Syme, A Bisello, CE Magyar, MD Rochdi… - Journal of Biological …, 2003 - ASBMB
Parathyroid hormone (PTH) regulates extracellular calcium homeostasis through the type 1
PTH receptor (PTH1R) expressed in kidney and bone. The PTH1R undergoes β-arrestin/…

Agonist-biased signaling via proteinase activated receptor-2: differential activation of calcium and mitogen-activated protein kinase pathways

R Ramachandran, K Mihara, M Mathur, MD Rochdi… - Molecular …, 2009 - ASPET
We evaluated the ability of different trypsin-revealed tethered ligand (TL) sequences of rat
proteinase-activated receptor 2 (rPAR 2 ) and the corresponding soluble TL-derived agonist …

[HTML][HTML] Role of the differentially spliced carboxyl terminus in thromboxane A2 receptor trafficking: identification of a distinct motif for tonic internalization

JL Parent, P Labrecque, MD Rochdi… - Journal of Biological …, 2001 - ASBMB
The thromboxane A 2 receptor (TP) is a G protein-coupled receptor that is expressed as two
alternatively spliced isoforms, α (343 residues) and β (407 residues) that share the first 328 …

[HTML][HTML] Unraveling G protein-coupled receptor endocytosis pathways using real-time monitoring of agonist-promoted interaction between β-arrestins and AP-2

FF Hamdan, MD Rochdi, B Breton, D Fessart… - Journal of biological …, 2007 - ASBMB
The most widely studied pathway underlying agonist-promoted internalization of G protein-coupled
receptors (GPCRs) involves β-arrestin and clathrin-coated pits. However, both β-…

[HTML][HTML] Nm23-H2 interacts with a G protein-coupled receptor to regulate its endocytosis through an Rac1-dependent mechanism

MD Rochdi, G Laroche, E Dupré, P Giguere… - Journal of Biological …, 2004 - ASBMB
G protein-coupled receptors (GPCRs) represent a vast family of transmembrane proteins
involved in the regulation of several physiological responses. The thromboxane A2 receptor (…

[HTML][HTML] Gαq-coupled Receptor Internalization Specifically Induced by Gαq Signaling: REGULATION BY EBP50

MD Rochdi, JL Parent - Journal of Biological Chemistry, 2003 - ASBMB
In the present report, we investigated the effect of ezrin-radixin-moesin-binding phosphoprotein
50 (EBP50) expression on the agonist-induced internalization of the thromboxane A 2 β …

Differential regulation of the signaling and trafficking of the two prostaglandin D2 receptors, prostanoid DP receptor and CRTH2

MA Gallant, D Slipetz, É Hamelin, MD Rochdi… - European journal of …, 2007 - Elsevier
Prostaglandin D 2 (PGD 2 ) exerts its actions on two G protein-coupled receptors, the prostanoid
DP receptor and CRTH2 (chemoattractant homologous receptor expressed on TH2 cells…

[HTML][HTML] Regulation of GTP-binding protein αq (Gαq) signaling by the ezrin-radixin-moesin-binding phosphoprotein-50 (EBP50)

MD Rochdi, V Watier, C La Madeleine, H Nakata… - Journal of Biological …, 2002 - ASBMB
Although ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) is a PDZ domain-containing
protein known to bind to various channels, receptors, cytoskeletal elements, and …

Distinct motifs of neuropeptide Y receptors differentially regulate trafficking and desensitization

M Ouedraogo, S Lecat, MD Rochdi, M Hachet‐Haas… - Traffic, 2008 - Wiley Online Library
Activated human neuropeptide YY 1 receptors rapidly desensitize and internalize through
clathrin‐coated pits and recycle from early and recycling endosomes, unlike Y 2 receptors that …

Role of the Rab11-Associated Intracellular Pool of Receptors Formed by Constitutive Endocytosis of the β Isoform of the Thromboxane A2 Receptor (TPβ)

C Thériault, MD Rochdi, JL Parent - Biochemistry, 2004 - ACS Publications
Intracellular trafficking pathways of G protein-coupled receptors (GPCRs), following their
agonist-induced endocytosis and their consequences on receptor function, are the subject of …