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[PDF][PDF] Novel adamantane derivatives act as blockers of open ligand-gated channels and as anticonvulsants.

…, JW Johnson, NY Lukomskaya, NN Potapyeva… - Molecular …, 1995 - Citeseer
We examined the influence of the molecular structure of four novel adamantane derivatives
on their ability to block the chan-nels of nicotinic acetylcholine(ACh) and N-methyl-D-…

Dimensions of the ion channel in neuronal nicotinic acetylcholine receptor as estimated from analysis of conformation-activity relationships of open-channel blocking …

…, NY Lukomskaya, SE Serdyuk, NN Potapyeva… - The Journal of …, 1991 - Springer
Relationship between the size of the molecule in the series of organic ions Et 3 N−(CH 2 ) 5
−N + R 1 R 2 R 3 (R i -alkyl or cycloalkyl substituents) and their abilities to block nicotinic …

[HTML][HTML] Kinked-helices model of the nicotinic acetylcholine receptor ion channel and its complexes with blockers: simulation by the Monte Carlo minimization method

DB Tikhonov, BS Zhorov - Biophysical journal, 1998 - cell.com
A model of the nicotinic acetylcholine receptor ion channel was elaborated based on the
data from electron microscopy, affinity labeling, cysteine scanning, mutagenesis studies, and …

[HTML][HTML] Chloride channels of glycine and GABA receptors with blockers: Monte Carlo minimization and structure-activity relationships

BS Zhorov, PD Bregestovski - Biophysical Journal, 2000 - cell.com
GABA and glycine receptors (GlyRs) are pentameric ligand-gated ion channels that respond
to the inhibitory neurotransmitters by opening a chloride-selective central pore lined with …

Na+, K+-ATPase functionally interacts with the plasma membrane Na+, Ca2+ exchanger to prevent Ca2+ overload and neuronal apoptosis in excitotoxic stress

DA Sibarov, AE Bolshakov, PA Abushik, II Krivoi… - … of Pharmacology and …, 2012 - ASPET
Using a fluorescent viability assay, immunocytochemistry, patch-clamp recordings, and Ca 2+
imaging analysis, we report that ouabain, a specific ligand of the Na + ,K + -ATPase …

Design of antagonists for NMDA and AMPA receptors

KV Bolshakov, KH Kim, NN Potapjeva, VE Gmiro… - …, 2005 - Elsevier
Determinants of antagonism of NMDA and calcium permeable AMPA receptor channels by
organic cations were studied using several homologous series of mono- and dicationic …

[HTML][HTML] Quantitative analysis of tetrapentylammonium-induced blockade of open N-methyl-D-aspartate channels

AI Sobolevsky - Biophysical Journal, 2000 - cell.com
The blockade of open N-methyl-d-aspartate (NMDA) channels by tetrapentylammonium (TPentA)
in acutely isolated rat hippocampal neurons was studied using whole-cell patch-clamp …

Structural characteristics of ionotropic glutamate receptors as identified by channel blockade

…, NA Dorofeeva, NY Lukomskaya, NN Potap'eva… - Neuroscience and …, 2002 - Springer
The channels of four types of ionotropic glutamate receptor (NMDA receptors and Ca-permeable
AMPA receptors of rat brain neurons, and cation-selective receptors from mollusk …

[HTML][HTML] Intersegment hydrogen bonds as possible structural determinants of the N/Q/R site in glutamate receptors

DB Tikhonov, BS Zhorov, LG Magazanik - Biophysical journal, 1999 - cell.com
Specific electrophysiological and pharmacological properties of ionic channels in NMDA,
AMPA, and kainate subtypes of ionotropic glutamate receptors (GluRs) are determined by the …

[CITATION][C] DIMENSIONS OF NARROW SPOT IN NICOTINIC CHOLINORECEPTOR ION CHANNEL DERIVED FROM ANALYSIS OF CONFORMATION-ACTIVITY …

…, SE Serdyuk, NN Potapyeva… - …, 1989 - MEZHDUNARODNAYA KNIGA 39 …
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