Involvement of reactive oxygen species in angiotensin II-induced endothelin-1 gene expression in rat cardiac fibroblasts
TH Cheng, PY Cheng, NL Shih, IB Chen… - Journal of the American …, 2003 - jacc.org
Objectives : The aim of this study was to investigate the effects of angiotensin II (Ang II) on
fibroblast proliferation and endothelin-1 (ET-1) gene induction, focusing especially on reactive …
fibroblast proliferation and endothelin-1 (ET-1) gene induction, focusing especially on reactive …
Reactive oxygen species mediate cyclic strain-induced endothelin-1 gene expression via Ras/Raf/extracellular signal-regulated kinase pathway in endothelial cells
TH Cheng, NL Shih, SY Chen, SH Loh… - Journal of molecular and …, 2001 - Elsevier
Endothelin-1 (Et-1) is a peptide synthesized by endothelial cells (ECs) both in culture and in
vivo. Cyclic strain induces gene expression of Et-1, however, the molecular mechanisms …
vivo. Cyclic strain induces gene expression of Et-1, however, the molecular mechanisms …
Reactive oxygen species generation is involved in epidermal growth factor receptor transactivation through the transient oxidization of Src homology 2-containing …
CH Chen, TH Cheng, H Lin, NL Shih, YL Chen… - Molecular …, 2006 - ASPET
Endothelin-1 (ET-1) is implicated in fibroblast proliferation, which results in cardiac fibrosis.
Both reactive oxygen species (ROS) generation and epidermal growth factor receptor (EGFR…
Both reactive oxygen species (ROS) generation and epidermal growth factor receptor (EGFR…
Reactive oxygen species modulate angiotensin II-induced β-myosin heavy chain gene expression via ras/raf/extracellular signal-regulated kinase pathway in neonatal …
NL Shih, TH Cheng, SH Loh, PY Cheng… - Biochemical and …, 2001 - Elsevier
Angiotensin II (Ang II) causes cardiomyocytes hypertrophy. Cardiac β-myosin heavy chain (β-MyHC)
gene expression can be altered by Ang II. The molecular mechanisms are not …
gene expression can be altered by Ang II. The molecular mechanisms are not …
Role of mitogen-activated protein kinase pathway in reactive oxygen species-mediated endothelin-1-induced β-myosin heavy chain gene expression and …
TH Cheng, NL Shih, CH Chen, H Lin, JC Liu… - Journal of biomedical …, 2005 - Springer
Endothelin-1 (ET-1) has been found to increase cardiac β-myosin heavy chain (β-MyHC)
gene expression and induce hypertrophy in cardiomyocytes. ET-1 has been demonstrated to …
gene expression and induce hypertrophy in cardiomyocytes. ET-1 has been demonstrated to …
Crucial role of extracellular signal-regulated kinase pathway in reactive oxygen species-mediated endothelin-1 gene expression induced by endothelin-1 in rat …
CM Cheng, HJ Hong, JC Liu, NL Shih, SH Juan… - Molecular …, 2003 - ASPET
Endothelin-1 (ET-1) has been implicated in fibroblast proliferation. However, the mechanism
involving ET-1 is not clear. The present study was performed to examine the role of …
involving ET-1 is not clear. The present study was performed to examine the role of …
Inhibitory effect of resveratrol on angiotensin II-induced cardiomyocyte hypertrophy
TH Cheng, JC Liu, H Lin, NL Shih, YL Chen… - Naunyn-Schmiedeberg's …, 2004 - Springer
Resveratrol is proposed to account in part for the protective effect of red wine on the cardiovascular
system. Angiotensin II (Ang II) is a potent hypertrophic stimulus in cardiomyocytes. In …
system. Angiotensin II (Ang II) is a potent hypertrophic stimulus in cardiomyocytes. In …
Nitric oxide inhibits endothelin-1-induced cardiomyocyte hypertrophy through cGMP-mediated suppression of extracellular-signal regulated kinase phosphorylation
TH Cheng, NL Shih, SY Chen, JW Lin, YL Chen… - Molecular …, 2005 - ASPET
Cardiac hypertrophy is a compensatory mechanism in response to a variety of
cardiovascular diseases. Recently, reactive oxygen species and nitric oxide (NO) have been …
cardiovascular diseases. Recently, reactive oxygen species and nitric oxide (NO) have been …
Heme oxygenase-1 contributes to the cytoprotection of alpha-lipoic acid via activation of p44/42 mitogen-activated protein kinase in vascular smooth muscle cells
PY Cheng, YM Lee, NL Shih, YC Chen… - Free Radical Biology and …, 2006 - Elsevier
Alpha-lipoic acid (ALA) is a natural antioxidant that scavenges reactive oxygen species (ROS)
and regenerates or recycles endogenous antioxidants. ALA has recently been reported to …
and regenerates or recycles endogenous antioxidants. ALA has recently been reported to …
[HTML][HTML] Inhibitory effects of momordicine I on high-glucose-induced cell proliferation and collagen synthesis in rat cardiac fibroblasts
PY Chen, NL Shih, WR Hao, CC Chen… - … medicine and cellular …, 2018 - hindawi.com
Diabetes-associated cardiac fibrosis is a severe cardiovascular complication. Momordicine I,
a bioactive triterpenoid isolated from bitter melon, has been demonstrated to have …
a bioactive triterpenoid isolated from bitter melon, has been demonstrated to have …