The combination of obesity and type 2 diabetes is a serious health problem, which is projected
to afflict 300 million people worldwide by 2020. Both clinical and translational laboratory …

Stroke is a leading cause of death and long-term disability in industrialized countries.
Despite advances in understanding its pathophysiology, little progress has been made in the …

Erythropoietin (EPO), a member of the type 1 cytokine superfamily, plays a critical hormonal
role regulating erythrocyte production as well as a paracrine/autocrine role in which locally …

Inhibition of inducible nitric oxide synthase reduces renal ischemia/reperfusion injury. Background
Nitric oxide (NO), produced via inducible nitric oxide synthase (iNOS), is implicated in …

Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone
receptor superfamily of ligand-activated transcription factors that are related to retinoid, …

… Author links open overlay panel Nimesh SA Patel , Edward J. Sharples , Salvatore Cuzzocrea
, Prabal K. Chatterjee , Domenico Britti , … PK Chatterjee, NSA Patel, A. Sivarajah, et al. …

In normal conditions, nitric oxide (NO) is oxidized to the anion nitrite, but in hypoxia, this nitrite
may be reduced back to NO by the nitrite reductase action of deoxygenated hemoglobin, …

Here, we investigate the effects of renal ischemia/reperfusion (I/R) on the degree of renal
injury, dysfunction, and inflammation in interleukin (IL)-6 knockout (IL-6 -/- ) mice and mice …

The generation of endogenous hydrogen sulfide may either limit or contribute to the degree
of tissue injury caused by ischemia/reperfusion. A total of 74 male Wistar rats were used to …

Background/Aims: Recent evidence indicates that peroxisome-proliferator activated receptor
(PPAR) agonists protect against ischemia/reperfusion (I/R) injury. Here we investigate the …