Tyrosine kinase inhibitors (TKIs) are promising new agents for specific inhibition of
malignant cell growth and metastasis formation. Because most of the TKIs have to reach an …

Iressa (ZD1839, Gefitinib), used in clinics to treat non–small cell lung cancer patients, is a
tyrosine kinase receptor inhibitor that leads to specific decoupling of epidermal growth factor …

The human ABCG2 protein is an important primary active transporter for hydrophobic
compounds in several cell types, and its overexpression causes multidrug resistance in tumors. A …

Porcine induced pluripotent stem cells (piPSCs) have the capacity to differentiate in vitro
and in vivo and form chimeras. However, the lack of transgene silencing of exogenous DNA …

Cell proliferation and differentiation are highly coordinated processes during normal
development. Most leukemia cells are blocked from undergoing terminal differentiation and also …

Induced pluripotent stem (iPS) cell technology involves reprogramming somatic cells to a
pluripotent state. The original technology used to produce these cells requires viral gene …

Ring1 and Yy1 binding protein (Rybp) has been implicated in transcriptional regulation,
apoptotic signaling and as a member of the polycomb repressive complex 1, it has an important …

Stem cell-based gene therapy is often unsuccessful because of the relatively low number of
genetically modified cells with repopulating capabilities. To provide a selective advantage …

Mutations in the gene coding for a human ABC transporter protein, ABCC6 (MRP6), are
responsible for the development of pseudoxanthoma elasticum. Here, we demonstrate that …

Mouse embryonic stem cells (ESCs) and induced pluripotent stem (iPS) cells can be used
as models of neuronal differentiation for the investigation of mammalian neurogenesis, …