A CTG repeat-selective chemical screen identifies microtubule inhibitors as selective modulators of toxic CUG RNA levels

K Reddy, JR Jenquin, OL McConnell… - Proceedings of the …, 2019 - National Acad Sciences
A CTG repeat expansion in the DMPK gene is the causative mutation of myotonic dystrophy
type 1 (DM1). Transcription of the expanded CTG repeat produces toxic gain-of-function …

An engineered RNA binding protein with improved splicing regulation

…, JI Richardson, RC Day, OL McConnell… - Nucleic acids …, 2018 - academic.oup.com
The muscleblind-like (MBNL) family of proteins are key developmental regulators of
alternative splicing. Sequestration of MBNL proteins by expanded CUG/CCUG repeat RNA …

Conservation of context-dependent splicing activity in distant Muscleblind homologs

JC Oddo, T Saxena, OL McConnell… - Nucleic acids …, 2016 - academic.oup.com
The Muscleblind (MBL) protein family is a deeply conserved family of RNA binding proteins
that regulate alternative splicing, alternative polyadenylation, RNA stability and RNA …

Automated intracellular pharmacological electrophysiology for ligand-gated ionotropic receptor and pharmacology screening

RE Perszyk, MC Yip, OL McConnell, ET Wang… - Molecular …, 2021 - ASPET
Communication between neuronal cells, which is central to brain function, is performed by
several classes of ligand-gated ionotropic receptors. The gold-standard technique for …

[PDF][PDF] Impeding transcription of expanded microsatellite repeats by deactivated Cas9

…, JD Cleary, LT Denes, O McConnell… - Molecular cell, 2017 - cell.com
Transcription of expanded microsatellite repeats is associated with multiple human diseases,
including myotonic dystrophy, Fuchs endothelial corneal dystrophy, and C9orf72-ALS/FTD. …

Preparation of 1-hydroxyalkylidenediphosphonates

RL McConnell, HW Coover Jr - Journal of the American Chemical …, 1956 - ACS Publications
… (0)P(0)(OC2Hs)2, initially formed, to give CH3C(ONa)[P(0)(0C2H5)2]2 which was followed
by acetylation of the ONa group by the acetyl chloride. We have found that dialkyl hydrogen …

RNA structure probing to characterize RNA–protein interactions on low abundance pre-mRNA in living cells

JL Bubenik, M Hale, O McConnell, ET Wang… - RNA, 2021 - rnajournal.cshlp.org
In vivo RNA structure analysis has become a powerful tool in molecular biology, largely due
to the coupling of an increasingly diverse set of chemical approaches with high-throughput …

Periodic structures in lipid monolayer phase transitions

HM McConnell, LK Tamm… - Proceedings of the …, 1984 - National Acad Sciences
… Thesolid domains form a quasi-hexagonal lattice on aqueous substrates. To determine
whether or not the charge on the lipid probe has any effect on solid-phase domain formation, we …

Functional synaptic circuits in the subplate during fetal and early postnatal development of cat visual cortex

E Friauf, SK McConnell, CJ Shatz - Journal of Neuroscience, 1990 - Soc Neuroscience
… The axonal processes of subplate neurons were remarkable in that many not only arborized
… Most of the axonal branches enter the cortical plate. Cell body and dendrites of this multi…

Neutron measurements in near‐Earth orbit with COMPTEL

…, JA Lockwood, ML McConnell… - Journal of …, 1995 - Wiley Online Library
… The effect of the spa½•raœt mass in shielding •e clct•tor from the atmospheric neutron all•clo
is much more imporient than its role • a source of aclcli•onal se½onclar¾ neutrons. •he …