The metabolism of 5, 1 0-dideazatetrahydrofolate(DDATHF [lometrexol]) to polyglutamate
derivatives by folylpoly-y-gluta-mate synthetase(FPGS) plays a central role in the activity of this …

… Moran, RG, and PD Colman, Mammalian folylpolyglutamate synthetase: partial
purification and properties of the mouse liver enzyme. Biochemistry 23:4580-4589 (1984). …

Previous methods for the measurement of folylpolyglutamate synthetase have been modified
and combined to facilitate assay of this enzyme at the levels found in mammalian tissues. …

Richard G. Moran* and Paul D. Colman abstract: Folyl polyglutamate synthetase has been
partially purified from mouse liver, and the general features of this enzyme have been …

γ-Phosphonate analogues of methotrexate (MTX) and aminopterin (AMT) were synthesized
from 4-amino-4-deoxy-N 10 -methylpteroic acid and 4-amino-4-deoxy-N 10 -formylpteroic …

To evaluate whether major age‐related changes occur during aging in the brain, we determined
the sequence complexity of total poly(A)RNA and polysomal poly(A)RNA of brains from …

The 5-position of tetrahydrofolate was found to be unusually reactive with low concentrations
of formic acid in the presence of a water-soluble carbodiimide. The product of this reaction …

Over the last 3 years angioscopic techniques have been used to guide intraluminal instrumentation
in 73 patients undergoing thrombectomy, nine patients with vascular trauma, and 32 …

… COLMAN and Philip FEIGELSON Previous reports from this laboratory have established that
rat liver … A preliminary report of these studies has appeared (Colman and Feigelson, 1975). …

Several structurally related series of folate analogs were studied as substrates for mouse
liver folylpolyglutamate synthetase (FPGS). A comparison of the kinetics of the interaction of …