The field of nanotechnology mainly encompasses with biology, physics, chemistry and
material sciences and it develops novel therapeutic nanosized materials for biomedical and …

Nitric oxide (NO) is an important regulator of a variety of biological functions, and also has a
role in the pathogenesis of cellular injury. It had been generally accepted that NO is solely …

… -1 and thrombin have been shown to activate NAD(P)H oxidase23. Treatment of VSMCs
with Ang II causes an increase in expression of NAD(P)H oxidase as well as ROS production24,…

The polyamines are small organic cations that are absolutely required for eukaryotic cell
growth. Although their growth requirements are well established, the molecular functions of the …

Mitochondrial dysfunction is a hallmark of β-amyloid (Aβ)–induced neuronal toxicity in
Alzheimer's disease (AD). Here, we demonstrate that Aβ-binding alcohol dehydrogenase (ABAD) …

… ischaemia on myocardial pH by in vivo "P nuclear magnetic resonance (NMR) spectroscopy,
… Zweier, JL, Wang, P. & Kuppusamy, P. Direct measurement of nitric oxide generation in the …

… and imaging techniques and shown that tumor tissues are highly reducing and hypoxic
compared with normal tissues (P. Kuppusamy et al., Cancer Res., 58: 1562–1568, 1998). The …

Previous in vitro studies have shown that isolated mitochondria can generate oxygen radicals.
However, whether a similar phenomenon can also occur in intact organs is unknown. In …

Oxygen free radicals have been demonstrated to be important mediators of postischemic
reperfusion injury in a broad variety of tissues; however, the cellular source of free radical …

Lucigenin is most noted for its wide use as a chemiluminescent detector of superoxide
anion radical (O·̄ 2 ) production by biological systems. However, its validity as a O·̄ 2 -detecting …