Suppression of lipopolysaccharide-induced tumor necrosis factor-alpha generation from human peripheral blood monocytes by inhibitors of phosphodiesterase 4 …
PM Seldon, PJ Barnes, K Meja, MA Giembycz - Molecular Pharmacology, 1995 - ASPET
We assessed the role of cyclic nucleotides in modulating lipopolysaccharide (LPS)-induced
tumor necrosis factor-alpha (TNF-alpha) generation in human peripheral blood monocytes. …
tumor necrosis factor-alpha (TNF-alpha) generation in human peripheral blood monocytes. …
Release of granulocyte‐macrophage colony stimulating factor by human cultured airway smooth muscle cells: suppression by dexamethasone
MA Saunders, JA Mitchell, PM Seldon… - British journal of …, 1997 - Wiley Online Library
Smooth muscle cells represent a significant percentage of the total cells in the airway but
their contribution to the inflammatory response seen in airway disease has not been studied. …
their contribution to the inflammatory response seen in airway disease has not been studied. …
p38 MAP kinase and MKK‐1 co‐operate in the generation of GM‐CSF from LPS‐stimulated human monocytes by an NF‐κB‐independent mechanism
KK Meja, PM Seldon, Y Nasuhara, K Ito… - British journal of …, 2000 - Wiley Online Library
The extent to which the p38 mitogen‐activated protein (MAP) kinase and MAP kinase kinase
(MKK)‐1‐signalling pathways regulate the expression of granulocyte/macrophage colony‐…
(MKK)‐1‐signalling pathways regulate the expression of granulocyte/macrophage colony‐…
Interleukin-10 does not mediate the inhibitory effect of PDE-4 inhibitors and other cAMP-elevating drugs on lipopolysaccharide-induced tumors necrosis factor-α …
PM Seldon, PJ Barnes, MA Giembycz - Cell biochemistry and biophysics, 1998 - Springer
Lipopolysaccharide (LPS)-induced liver injury in mice and LPS-induced tumor necrosis factor-α
(TNF-α) generation by murine macrophages and hepatocytes are suppressed markedly …
(TNF-α) generation by murine macrophages and hepatocytes are suppressed markedly …
Suppression of granulocyte/macrophage colony‐stimulating factor release from human monocytes by cyclic AMP‐elevating drugs: role of interleukin‐10
PM Seldon, MA Giembycz - British journal of pharmacology, 2001 - Wiley Online Library
… Paul M Seldon … Paul M Seldon … released confirming previous reports that IL-10 is generated
in response to LPS (Seldon et al., 1998b) and acts in a negative autocrine factor to temper …
in response to LPS (Seldon et al., 1998b) and acts in a negative autocrine factor to temper …
Rolipram, salbutamol and prostaglandin E2 suppress TNFα release from human monocytes by activating Type II cAMP-dependent protein kinase
PM Seldon, KK Meja, MA Giembycz - Pulmonary pharmacology & …, 2005 - Elsevier
The extent to which cAMP-dependent protein kinase (PKA) mediates the inhibitory effects of
cAMP-elevating drugs on tumour necrosis factor (TNF) α release from lipopolysaccharide (…
cAMP-elevating drugs on tumour necrosis factor (TNF) α release from lipopolysaccharide (…
Albuterol does not antagonize the inhibitory effect of dexamethasone on monocyte cytokine release
PM Seldon, DA Stevens, IM Adcock… - American journal of …, 1998 - atsjournals.org
… As shown in Figure 1, treatment of human monocytes with dexamethasone (100 pM to
300 nM) inhibited LPS-induced TNFα and GM-CSF generation in a concentration-dependent …
300 nM) inhibited LPS-induced TNFα and GM-CSF generation in a concentration-dependent …
Pharmacological characterization of a receptor for platelet-activating factor on guinea pig peritoneal macrophages using [3H] apafant, a selective and competitive …
PC Ring, PM Seldon, PJ Barnes, MA Giembycz - Molecular pharmacology, 1993 - ASPET
In this paper we report the characterization of a receptor for platelet-activating factor (PAF)
on guinea pig peritoneal macrophages, using a radiolabeled hydrophilic PAF antagonist, [3H] …
on guinea pig peritoneal macrophages, using a radiolabeled hydrophilic PAF antagonist, [3H] …
[BOOK][B] The Impossible Office?: The History of the British Prime Minister-Revised and Updated
A Seldon, J Meakin, I Thoms, T Egerton - 2024 - books.google.com
… Seldon discusses which of our PMs have been most effective and why, as well as probing the
changing relationship between the monarchy and the prime minister … Sir Anthony Seldon is …
changing relationship between the monarchy and the prime minister … Sir Anthony Seldon is …
[BOOK][B] Blair unbound
A Seldon, P Snowdon, D Collings - 2008 - books.google.com
… up ideas to announce himself once he became Prime Minister, as shown by his adopting
Blair… –but for a man who expected very soon to become Prime Minister? In the third term, Blair’s …
Blair… –but for a man who expected very soon to become Prime Minister? In the third term, Blair’s …