[HTML][HTML] The cancer microbiome: distinguishing direct and indirect effects requires a systemic view

…, T Korem, BJM Webb-Robertson, MP Styczynski… - Trends in cancer, 2020 - cell.com
The collection of microbes that live in and on the human body – the human microbiome –
can impact on cancer initiation, progression, and response to therapy, including cancer …

The vitamin A ester retinyl propionate has a unique metabolic profile and higher retinoid‐related bioactivity over retinol and retinyl palmitate in human skin models

…, RL Adams, JD Sherrill, PB Styczynski… - Experimental …, 2021 - Wiley Online Library
… Moreover, the higher lipophilicity of RPalm (log P 13.8) versus ROL (log P 5.7) and RP (log
P 6.7) makes it more likely to remain in the phospholipid bilayers of keratinocytes cellular …

Precision metabolic engineering: the design of responsive, selective, and controllable metabolic systems

MP McNerney, DM Watstein, MP Styczynski - Metabolic engineering, 2015 - Elsevier
Metabolic engineering is generally focused on static optimization of cells to maximize production
of a desired product, though recently dynamic metabolic engineering has explored how …

Low-cost, point-of-care biomarker quantification

F Piorino, AT Patterson, MP Styczynski - Current opinion in biotechnology, 2022 - Elsevier
Highlights • Quantification of biomarkers is necessary for the diagnosis of many diseases. •
Low-cost, point-of-care biomarker quantification remains a challenge. • New technologies, …

Systematic identification of conserved metabolites in GC/MS data for metabolomics and biomarker discovery

MP Styczynski, JF Moxley, LV Tong, JL Walther… - Analytical …, 2007 - ACS Publications
Analysis of metabolomic profiling data from gas chromatography−mass spectrometry (GC/MS)
measurements usually relies upon reference libraries of metabolite mass spectra to …

BLOSUM62 miscalculations improve search performance

MP Styczynski, KL Jensen, I Rigoutsos… - Nature …, 2008 - nature.com
The BLOSUM1 family of substitution matrices, and particularly BLOSUM62, is the de facto
standard in protein database searches and sequence alignments. In the course of analyzing …

[HTML][HTML] Applications of metabolomics in cancer research

KA Vermeersch, MP Styczynski - Journal of carcinogenesis, 2013 - ncbi.nlm.nih.gov
The first discovery of metabolic changes in cancer occurred almost a century ago. While the
genetic underpinnings of cancer have dominated its study since then, altered metabolism …

Cloning and expression of a rat-liver phenobarbital-inducible UDP-glucuronosyltransferase (2B12) with specificity for monoterpenoid alcohols

MD Green, DJ Clarke, EM Oturu, PB Styczynski… - Archives of Biochemistry …, 1995 - Elsevier
A full-length cDNA, HBPA2, that encodes for a new rat hepatic UDP-glucuronosyltransferase
protein, designated UGT2B12, was isolated from a rat liver cDNA library. The isolated clone …

The direct glucuronidation of 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine by human and rabbit liver microsomes

PB Styczynski, RC Blackmon… - Chemical research in …, 1993 - ACS Publications
… Glucuronidation assays for morphine, p-nitrophenol, and tripelennamine were performed
as previously described (12-14). The extent of PhIP glucuronidation was measured using …

Point-of-care biomarker quantification enabled by sample-specific calibration

…, AD Silverman, MC Jewett, MP Styczynski - Science …, 2019 - science.org
Easy-to-perform, relatively inexpensive blood diagnostics have transformed at-home healthcare
for some patients, but they require analytical equipment and are not easily adapted to …