[HTML][HTML] The cancer microbiome: distinguishing direct and indirect effects requires a systemic view
The collection of microbes that live in and on the human body – the human microbiome –
can impact on cancer initiation, progression, and response to therapy, including cancer …
can impact on cancer initiation, progression, and response to therapy, including cancer …
The vitamin A ester retinyl propionate has a unique metabolic profile and higher retinoid‐related bioactivity over retinol and retinyl palmitate in human skin models
…, RL Adams, JD Sherrill, PB Styczynski… - Experimental …, 2021 - Wiley Online Library
… Moreover, the higher lipophilicity of RPalm (log P 13.8) versus ROL (log P 5.7) and RP (log
P 6.7) makes it more likely to remain in the phospholipid bilayers of keratinocytes cellular …
P 6.7) makes it more likely to remain in the phospholipid bilayers of keratinocytes cellular …
Precision metabolic engineering: the design of responsive, selective, and controllable metabolic systems
MP McNerney, DM Watstein, MP Styczynski - Metabolic engineering, 2015 - Elsevier
Metabolic engineering is generally focused on static optimization of cells to maximize production
of a desired product, though recently dynamic metabolic engineering has explored how …
of a desired product, though recently dynamic metabolic engineering has explored how …
Low-cost, point-of-care biomarker quantification
F Piorino, AT Patterson, MP Styczynski - Current opinion in biotechnology, 2022 - Elsevier
Highlights • Quantification of biomarkers is necessary for the diagnosis of many diseases. •
Low-cost, point-of-care biomarker quantification remains a challenge. • New technologies, …
Low-cost, point-of-care biomarker quantification remains a challenge. • New technologies, …
Systematic identification of conserved metabolites in GC/MS data for metabolomics and biomarker discovery
MP Styczynski, JF Moxley, LV Tong, JL Walther… - Analytical …, 2007 - ACS Publications
Analysis of metabolomic profiling data from gas chromatography−mass spectrometry (GC/MS)
measurements usually relies upon reference libraries of metabolite mass spectra to …
measurements usually relies upon reference libraries of metabolite mass spectra to …
BLOSUM62 miscalculations improve search performance
The BLOSUM1 family of substitution matrices, and particularly BLOSUM62, is the de facto
standard in protein database searches and sequence alignments. In the course of analyzing …
standard in protein database searches and sequence alignments. In the course of analyzing …
[HTML][HTML] Applications of metabolomics in cancer research
KA Vermeersch, MP Styczynski - Journal of carcinogenesis, 2013 - ncbi.nlm.nih.gov
The first discovery of metabolic changes in cancer occurred almost a century ago. While the
genetic underpinnings of cancer have dominated its study since then, altered metabolism …
genetic underpinnings of cancer have dominated its study since then, altered metabolism …
Cloning and expression of a rat-liver phenobarbital-inducible UDP-glucuronosyltransferase (2B12) with specificity for monoterpenoid alcohols
MD Green, DJ Clarke, EM Oturu, PB Styczynski… - Archives of Biochemistry …, 1995 - Elsevier
A full-length cDNA, HBPA2, that encodes for a new rat hepatic UDP-glucuronosyltransferase
protein, designated UGT2B12, was isolated from a rat liver cDNA library. The isolated clone …
protein, designated UGT2B12, was isolated from a rat liver cDNA library. The isolated clone …
The direct glucuronidation of 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine by human and rabbit liver microsomes
PB Styczynski, RC Blackmon… - Chemical research in …, 1993 - ACS Publications
… Glucuronidation assays for morphine, p-nitrophenol, and tripelennamine were performed
as previously described (12-14). The extent of PhIP glucuronidation was measured using …
as previously described (12-14). The extent of PhIP glucuronidation was measured using …
Point-of-care biomarker quantification enabled by sample-specific calibration
Easy-to-perform, relatively inexpensive blood diagnostics have transformed at-home healthcare
for some patients, but they require analytical equipment and are not easily adapted to …
for some patients, but they require analytical equipment and are not easily adapted to …