Lung organogenesis

…, F Sala, O Rogers, S De Langhe, PJ Kemp… - Current topics in …, 2010 - Elsevier
Developmental lung biology is a field that has the potential for significant human impact: lung
disease at the extremes of age continues to cause major morbidity and mortality worldwide…

The calcium-sensing receptor beyond extracellular calcium homeostasis: conception, development, adult physiology, and disease

D Riccardi, PJ Kemp - Annual review of physiology, 2012 - annualreviews.org
The extracellular calcium-sensing receptor (CaSR) is the first identified G protein–coupled
receptor to be activated by an ion, extracellular calcium (Ca 2+ ). Since the identification of the …

Carbon monoxide: an emerging regulator of ion channels

WJ Wilkinson, PJ Kemp - The Journal of physiology, 2011 - Wiley Online Library
Carbon monoxide is rapidly emerging as an important cellular messenger, regulating a wide
range of physiological processes. Crucial to its role in both physiology and disease is its …

Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel

…, J Bould, DE Iles, D Riccardi, C Peers, PJ Kemp - Science, 2004 - science.org
Modulation of calcium-sensitive potassium (BK) channels by oxygen is important in several
mammalian tissues, and in the carotid body it is crucial to respiratory control. However, the …

Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma

…, DT Ward, CJ Corrigan, JP T. Ward, PJ Kemp… - Science translational …, 2015 - science.org
Airway hyperresponsiveness and inflammation are fundamental hallmarks of allergic asthma
that are accompanied by increases in certain polycations, such as eosinophil cationic …

Allele-specific RNA interference rescues the long-QT syndrome phenotype in human-induced pluripotency stem cell cardiomyocytes

…, O Georgiou, MJ Patel, K Morgan, PJ Kemp… - European heart …, 2014 - academic.oup.com
Aims Long-QT syndromes (LQTS) are mostly autosomal-dominant congenital disorders
associated with a 1:1000 mutation frequency, cardiac arrest, and sudden death. We sought to …

Thiazide diuretics directly induce osteoblast differentiation and mineralized nodule formation by interacting with a sodium chloride co-transporter in bone

…, MA Knepper, G Gamba, PJ Kemp… - Journal of the …, 2007 - journals.lww.com
Thiazide diuretics are used worldwide as a first-choice drug for patients with uncomplicated
hypertension. In addition to their antihypertensive effect, thiazides increase bone mineral …

The vascular Ca2+-sensing receptor regulates blood vessel tone and blood pressure

…, SA Price, DH Edwards, PJ Kemp… - … of Physiology-Cell …, 2016 - journals.physiology.org
The extracellular calcium-sensing receptor CaSR is expressed in blood vessels where its
role is not completely understood. In this study, we tested the hypothesis that the CaSR …

A scaleable and defined system for generating neural stem cells from human embryonic stem cells

…, IA Bouhon, L Williams, K Westmore, PJ Kemp… - Stem …, 2007 - academic.oup.com
The ability to differentiate human ESCs (hESCs) to defined lineages in a totally controlled
manner is fundamental to developing cell-based therapies and studying human …

Forced cell cycle exit and modulation of GABAA, CREB, and GSK3β signaling promote functional maturation of induced pluripotent stem cell-derived neurons

…, AD Randall, ND Allen, PJ Kemp - … of Physiology-Cell …, 2016 - journals.physiology.org
Although numerous protocols have been developed for differentiation of neurons from a
variety of pluripotent stem cells, most have concentrated on being able to specify effectively …