Lung organogenesis
…, F Sala, O Rogers, S De Langhe, PJ Kemp… - Current topics in …, 2010 - Elsevier
Developmental lung biology is a field that has the potential for significant human impact: lung
disease at the extremes of age continues to cause major morbidity and mortality worldwide…
disease at the extremes of age continues to cause major morbidity and mortality worldwide…
The calcium-sensing receptor beyond extracellular calcium homeostasis: conception, development, adult physiology, and disease
D Riccardi, PJ Kemp - Annual review of physiology, 2012 - annualreviews.org
The extracellular calcium-sensing receptor (CaSR) is the first identified G protein–coupled
receptor to be activated by an ion, extracellular calcium (Ca 2+ ). Since the identification of the …
receptor to be activated by an ion, extracellular calcium (Ca 2+ ). Since the identification of the …
Carbon monoxide: an emerging regulator of ion channels
WJ Wilkinson, PJ Kemp - The Journal of physiology, 2011 - Wiley Online Library
Carbon monoxide is rapidly emerging as an important cellular messenger, regulating a wide
range of physiological processes. Crucial to its role in both physiology and disease is its …
range of physiological processes. Crucial to its role in both physiology and disease is its …
Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel
…, J Bould, DE Iles, D Riccardi, C Peers, PJ Kemp - Science, 2004 - science.org
Modulation of calcium-sensitive potassium (BK) channels by oxygen is important in several
mammalian tissues, and in the carotid body it is crucial to respiratory control. However, the …
mammalian tissues, and in the carotid body it is crucial to respiratory control. However, the …
Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma
…, DT Ward, CJ Corrigan, JP T. Ward, PJ Kemp… - Science translational …, 2015 - science.org
Airway hyperresponsiveness and inflammation are fundamental hallmarks of allergic asthma
that are accompanied by increases in certain polycations, such as eosinophil cationic …
that are accompanied by increases in certain polycations, such as eosinophil cationic …
Allele-specific RNA interference rescues the long-QT syndrome phenotype in human-induced pluripotency stem cell cardiomyocytes
…, O Georgiou, MJ Patel, K Morgan, PJ Kemp… - European heart …, 2014 - academic.oup.com
Aims Long-QT syndromes (LQTS) are mostly autosomal-dominant congenital disorders
associated with a 1:1000 mutation frequency, cardiac arrest, and sudden death. We sought to …
associated with a 1:1000 mutation frequency, cardiac arrest, and sudden death. We sought to …
Thiazide diuretics directly induce osteoblast differentiation and mineralized nodule formation by interacting with a sodium chloride co-transporter in bone
…, MA Knepper, G Gamba, PJ Kemp… - Journal of the …, 2007 - journals.lww.com
Thiazide diuretics are used worldwide as a first-choice drug for patients with uncomplicated
hypertension. In addition to their antihypertensive effect, thiazides increase bone mineral …
hypertension. In addition to their antihypertensive effect, thiazides increase bone mineral …
The vascular Ca2+-sensing receptor regulates blood vessel tone and blood pressure
…, SA Price, DH Edwards, PJ Kemp… - … of Physiology-Cell …, 2016 - journals.physiology.org
The extracellular calcium-sensing receptor CaSR is expressed in blood vessels where its
role is not completely understood. In this study, we tested the hypothesis that the CaSR …
role is not completely understood. In this study, we tested the hypothesis that the CaSR …
A scaleable and defined system for generating neural stem cells from human embryonic stem cells
…, IA Bouhon, L Williams, K Westmore, PJ Kemp… - Stem …, 2007 - academic.oup.com
The ability to differentiate human ESCs (hESCs) to defined lineages in a totally controlled
manner is fundamental to developing cell-based therapies and studying human …
manner is fundamental to developing cell-based therapies and studying human …
Forced cell cycle exit and modulation of GABAA, CREB, and GSK3β signaling promote functional maturation of induced pluripotent stem cell-derived neurons
…, AD Randall, ND Allen, PJ Kemp - … of Physiology-Cell …, 2016 - journals.physiology.org
Although numerous protocols have been developed for differentiation of neurons from a
variety of pluripotent stem cells, most have concentrated on being able to specify effectively …
variety of pluripotent stem cells, most have concentrated on being able to specify effectively …