Hormones in synergy: regulation of the pituitary gonadotropin genes

VG Thackray, PL Mellon, D Coss - Molecular and cellular endocrinology, 2010 - Elsevier
The precise interplay of hormonal influences that governs gonadotropin hormone production
by the pituitary includes endocrine, paracrine and autocrine actions of hypothalamic …

Immortalization of hypothalamic GnRH by genetically targeted tumorigenesis

PL Mellon, JJ Windle, PC Goldsmith, CA Padula… - Neuron, 1990 - cell.com
By genetically targeting tumorigenesis to specific hypothalamic neurons in transgenic mice
using the promoter region of the gonadotropin-releasing hormone (GnRH) gene to express …

Cell lines of the pituitary gonadotrope lineage derived by targeted oncogenesis in transgenic mice

JJ Windle, RI Weiner, PL Mellon - Molecular endocrinology, 1990 - academic.oup.com
… In addition, we have derived clonal cell lines of the hypothalamic neurosecretory neurons
that produce GnRH using this same approach (Mellon, PL, JJ Windle, PC Goldsmith, CA …

Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice

…, J Pattison, JG MacDonald, S Ylä-Herttuala, PL Mellon… - Nature, 2018 - nature.com
… The natural antibody E06 recognizes the hydrophilic phosphocholine headgroup of OxPL
that are present in OxLDL and apoptotic cells but does not recognize unoxidized PL in LDL or …

Cloning and functional expression of a mouse gonadotropin-releasing hormone receptor.

M Tsutsumi, W Zhou, RP Millar, PL Mellon… - Molecular …, 1992 - academic.oup.com
… Windle JJ, Weiner RI, Mellon PL 1990 Cell lines of the pituitary oonadotrope … MH, Bosma
MM, Windle JJ, Huber KS, Bount AL, Hille 8, Vale W, Mellon P 1991 Intracellular responses …

Immortalization of pituitary cells at discrete stages of development by directed oncogenesis in transgenic mice

ET Alarid, JJ Windle, DB Whyte, PL Mellon - Development, 1996 - journals.biologists.com
… One possible explanation for the presence of thyrotropes is that two independent clonal
transformation events may have taken place in the same pituitary giving rise to two cell types …

Intrinsic pulsatile secretory activity of immortalized luteinizing hormone-releasing hormone-secreting neurons.

…, FJ López, RI Weiner, PL Mellon… - Proceedings of the …, 1992 - National Acad Sciences
Mammalian reproduction is dependent upon intermittent delivery of luteinizing hormone-releasing
hormone (LHRH) to the anterior pituitary. This mode of secretion is required to …

Loss-of-function mutation in the prokineticin 2 gene causes Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism

…, EE Jacobson-Dickman, PL Mellon… - Proceedings of the …, 2007 - National Acad Sciences
Gonadotropin-releasing hormone (GnRH) deficiency in the human presents either as
normosmic idiopathic hypogonadotropic hypogonadism (nIHH) or with anosmia [Kallmann …

Negative regulation by glucocorticoids through interference with a cAMP responsive enhancer

IE Akerblom, EP Slater, M Beato, JD Baxter, PL Mellon - Science, 1988 - science.org
Although steroid hormone receptors are known to activate gene expression by binding to
specific hormone-dependent enhancers, the mechanisms by which steroids inhibit the …

Steroid and pulsatile gonadotropin-releasing hormone (GnRH) regulation of luteinizing hormone and GnRH receptor in a novel gonadotrope cell line.

…, Y Kimura, DW Waring, PL Mellon - Molecular …, 1996 - academic.oup.com
… lineage, Mellon and colleagues in earlier studies used a … , JJ Windle, DB Whyte, and PL
Mellon, submitted), which is expressed … 10 and ET Alarid, JJ Windle, DB Whyte, and PL Mellon, …