DDT, pyrethrins, pyrethroids and insect sodium channels

TGE Davies, LM Field, PNR Usherwood… - IUBMB …, 2007 - Wiley Online Library
The long term use of many insecticides is continually threatened by the ability of insects to
evolve resistance mechanisms that render the chemicals ineffective. Such resistance poses a …

The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels

…, AL Devonshire, PNR Usherwood - Pest management …, 2001 - Wiley Online Library
Recent progress in the cloning of α (para) and β (TipE) Na channel sub‐units from
Drosophila melanogaster (fruit fly) and Musca domestica (housefly) have facilitated functional …

Spider toxins as tools for dissecting elements of excitatory amino acid transmission

H Jackson, PNR Usherwood - Trends in neurosciences, 1988 - cell.com
During millions of years of evolution spiders have refined toxins which either paralyse or kill
their prey, but it is becoming increasingly clear that many of these chemicals are neurotoxins …

Activation of Drosophila Sodium Channels Promotes Modification by Deltamethrin: Reductions in Affinity Caused by Knock-down Resistance Mutations

…, JW Warmke, PNR Usherwood… - The Journal of general …, 2000 - rupress.org
… This work was supported by grants to PNR Usherwood (42/INS2999, 42/S10233) and AL
Devonshire (42/INS2999) from the British Biotechnology and Biological Sciences Research …

A comparative study of voltage‐gated sodium channels in the Insecta: implications for pyrethroid resistance in Anopheline and other Neopteran species

TGE Davies, LM Field, PNR Usherwood… - Insect molecular …, 2007 - Wiley Online Library
We report the complete cDNA sequence of the Anopheles gambiae voltage‐gated sodium
channel (VGSC) α‐subunit isolated from mature adult mosquitoes. The genomic DNA …

Block of open channels of recombinant AMPA receptors and native AMPA/kainate receptors by adamantane derivatives

…, VE Gmiro, IR Mellor, PNR Usherwood - The Journal of …, 1997 - Wiley Online Library
1 The effects of two adamantane derivatives, 1‐trimethylammonio‐5‐(l‐adamantane‐methylammoniopentane
dibromide) (IEM‐1460) and 1‐ammonio‐5‐(l‐adamantane‐…

[HTML][HTML] Mutations in DIIS5 and the DIIS4–S5 linker of Drosophila melanogaster sodium channel define binding domains for pyrethroids and DDT

PNR Usherwood, TGE Davies, IR Mellor, AO O'reilly… - Febs Letters, 2007 - Elsevier
Mutations in the DIIS4–S5 linker and DIIS5 have identified hotspots of pyrethroid and DDT
interaction with the Drosophila para sodium channel. Wild-type and mutant channels were …

Peripheral inhibition in skeletal muscle of insects

PNR Usherwood, H Grundfest - Journal of …, 1965 - journals.physiology.org
1s an important respect. In Crustacea well documented (cf. 24), and the mode of the inhibition,
through the conductance increase of the inhibitory postsynaptic membrane has been …

Non-Markovian character of ionic current fluctuations in membrane channels

…, Z Grzywna, I Mellor, Z Siwy, PNR Usherwood - Physical Review E, 1998 - APS
The Smoluchowski-Chapman-Kolmogorov functional equation presents the most basic test
of Markovian character of finite stochastic chains, and is simpler in application than other …

Structure and physiology of a chordotonal organ in the locust leg

PNR Usherwood, HI Runion… - Journal of Experimental …, 1968 - journals.biologists.com
PNR Usherwood (to be published) has recently found that this saline is in fact hypertonic
to the haemolymph of locusts and grasshoppers. Petroleum jelly and paraffin oil were also …