Two new rating scales for measuring the signs and symptoms of opiate withdrawal are
presented. The Subjective Opiate Withdrawal Scale (SOWS) contains 16 symptoms whose …

A large number of structurally diverse drugs with clinical antidepressant properties share
the ability to act as potent inhibitors of histamine-sensitive adenylate cyclase in cell-free …

Studies were conducted to investigate the clinical characteristics of naloxone-precipitated
withdrawal in human opioid-dependent subjects. Each of 20 male patients stabilized on 24 mg …

THERE is increasing interest in the possibility that histamine may be a neurotransmitter in
the mammalian central nervous system (CNS). Electrophysiological evidence supports the …

Objective The authors delineate the clinical characteristics of mood state changes that occur
in stable opioid-dependent patients undergoing therapeutic detoxification from methadone …

The effects of combined lesions of forebrain cholinergic and noradrenergic systems on memory
and responsitivity to the memory enhancing effects of cholinomimetics were investigated …

The efficacy of physostigmine on memory enhancement in rats trained on a passive
avoidance task was investigated. In experiment 1, the effect of posttraining injections of …

Levels of dysphoria and opioid dependence were assessed in 54 male patients with heroin
addiction applying for drug treatment. During a period of naturalistic heroin use, symptom …

Nerve growth factor (NGF) was injected into the lateral ventricle (5 μg on 4 occasions) of
rats which had previously sustained ibotenic acid-induced lesions of the nucleus basalis of …

The levels of opioid physical dependence in a group of long-term heroin addicts were
ascertained by measuring the severity of the opioid withdrawal syndrome before and after …