Many metabolic and physiological processes display circadian oscillations. We have shown
that the core circadian regulator, CLOCK, is a histone acetyltransferase whose activity is …

Circadian rhythms govern a large array of metabolic and physiological functions. The central
clock protein CLOCK has HAT properties. It directs acetylation of histone H3 and of its …

The mammalian circadian timing system is composed of almost as many individual clocks
as there are cells. These countless oscillators have to be synchronized by a central …

The ability to detect extracellular stimuli and execute the appropriate response is crucial to
all cellular functions. Upon receiving external signals, be it growth factor stimulation or …

The molecular machinery that governs circadian rhythmicity comprises proteins whose interplay
generates time-specific transcription of clock genes. The role of chromatin remodeling in …

X-linked adrenal hypoplasia congenita is a developmental disorder of the human adrenal
gland that results in profound hormonal deficiencies and is lethal if untreated. We have …

Histone acetylation and phosphorylation have separately been suggested to affect chromatin
structure and gene expression. Here we report that these two modifications are synergistic. …

Pituitary gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone
stimulate the gonads by regulating germ cell proliferation and differentiation. FSH receptors (FSH-Rs…

Coffin-Lowry Syndrome (CLS) is an X-linked mental retardation condition associated with
skeletal abnormalities. The gene mutated in CLS, RSK2, encodes a growth factor-regulated …

The circadian clock, a highly specialized, hierarchical network of biological pacemakers,
directs and maintains proper rhythms in endocrine and metabolic pathways required for …