Differential distribution of voltage‐gated calcium channel alpha‐2 delta (α2δ) subunit mRNA‐containing cells in the rat central nervous system and the dorsal root …
…, ME Williams, P Prodanovich… - Journal of …, 2005 - Wiley Online Library
Voltage‐gated calcium channels (VGCCs) play an essential role in controlling neurotransmitter
release, neuronal excitability, and gene expression in the nervous system. The …
release, neuronal excitability, and gene expression in the nervous system. The …
Human immunodeficiency virus type 1 mutants resistant to nonnucleoside inhibitors of reverse transcriptase arise in tissue culture.
…, I Lowy, J Rose, P Prodanovich… - Proceedings of the …, 1991 - National Acad Sciences
We have recently described a nonnucleoside compound that specifically inhibits the reverse
transcriptase of human immunodeficiency virus type 1 (HIV-1), the causative agent of AIDS. …
transcriptase of human immunodeficiency virus type 1 (HIV-1), the causative agent of AIDS. …
Pharmacological blockade of the DP2 receptor inhibits cigarette smoke-induced inflammation, mucus cell metaplasia, and epithelial hyperplasia in the mouse lung
…, NS Stock, AM Santini, P Fagan, P Prodanovich… - … of Pharmacology and …, 2010 - ASPET
Prostaglandin D 2 (PGD 2 ) is one of a family of biologically active lipids derived from arachidonic
acid via the action of COX-1 and COX-2. PGD 2 is released from mast cells and binds …
acid via the action of COX-1 and COX-2. PGD 2 is released from mast cells and binds …
Structural basis for inhibition of human autotaxin by four potent compounds with distinct modes of binding
AJ Stein, G Bain, P Prodanovich, AM Santini… - Molecular …, 2015 - ASPET
Autotaxin (ATX) is a secreted enzyme that hydrolyzes lysophosphatidylcholine to
lysophosphatidic acid (LPA). LPA is a bioactive phospholipid that regulates diverse biological …
lysophosphatidic acid (LPA). LPA is a bioactive phospholipid that regulates diverse biological …
Identification of 4-(aminomethyl)-6-(trifluoromethyl)-2-(phenoxy) pyridine derivatives as potent, selective, and orally efficacious inhibitors of the copper-dependent …
…, F Huang, J Darlington, P Prodanovich… - Journal of medicinal …, 2017 - ACS Publications
LOXL2 catalyzes the oxidative deamination of ε-amines of lysine and hydroxylysine residues
within collagen and elastin, generating reactive aldehydes (allysine). Condensation with …
within collagen and elastin, generating reactive aldehydes (allysine). Condensation with …
Small molecule lysyl oxidase-like 2 (LOXL2) inhibitors: the identification of an inhibitor selective for LOXL2 over LOX
…, D Lonergan, J Darlington, P Prodanovich… - ACS medicinal …, 2017 - ACS Publications
Two series of novel LOXL2 enzyme inhibitors are described: benzylamines substituted with
electron withdrawing groups at the para-position and 2-substituted pyridine-4-…
electron withdrawing groups at the para-position and 2-substituted pyridine-4-…
Selective inhibition of autotaxin is efficacious in mouse models of liver fibrosis
…, F Huang, J Darlington, L Goulet, P Prodanovich… - … of Pharmacology and …, 2017 - ASPET
Autotaxin (ATX) is a secreted glycoprotein that converts lysophosphatidylcholine (LPC) to
the bioactive phospholipid lysophosphatidic acid (LPA) and is the major enzyme generating …
the bioactive phospholipid lysophosphatidic acid (LPA) and is the major enzyme generating …
Structure and functional characterization of a novel human low‐voltage activated calcium channel
…, A Urrutia, PF Brust, P Prodanovich… - Journal of …, 1999 - Wiley Online Library
: We have isolated and characterized overlapping cDNAs encoding a novel, voltage‐gated
Ca 2+ channel α 1 subunit, α 1H , from a human medullary thyroid carcinoma cell line. The α …
Ca 2+ channel α 1 subunit, α 1H , from a human medullary thyroid carcinoma cell line. The α …
5-lipoxygenase-activating protein (FLAP) inhibitors. Part 4: Development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl) benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1 …
…, A Santini, J Darlington, P Prodanovich… - Journal of medicinal …, 2011 - ACS Publications
The potent 5-lipoxygenase-activating protein (FLAP) inhibitor 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-…
5-Lipoxygenase-Activating Protein Inhibitors: Development of 3-[3-tert-Butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2 …
…, C Lee, D Lorrain, P Prodanovich… - Journal of medicinal …, 2009 - ACS Publications
The potent and selective 5-lipoxygenase-activating protein leukotriene synthesis inhibitor 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-…