Brown adipose tissue (BAT) and skeletal muscle are important sites of nonshivering
thermogenesis. The uncoupling protein‐1 (UCP1) is the main effector of nonshivering …

Many homeostatic processes, including appetite and food intake, are controlled by neuroendocrine
circuits involving the CNS. The CNS also directly regulates adipocyte metabolism, as …

The uncoupling protein-1 (UCP1), cloned in 1985 (1–4) and called UCP until 1997, is an
inner mitochondrial membrane protein (5) expressed exclusively in the brown adipocyte (6–8). …

The mechanism by which long-term exposure of the β-cell to elevated concentrations of fatty
acid alters glucose-induced insulin secretion has been examined. Exposure of INS-1 β-cells …

White and brown adipocytes are usually located in distinct depots; however, in response to
cold, brown adipocytes appear in white fat. This response is mediated by β‐adrenoceptors …

The ob/ob mouse is genetically deficient in leptin and exhibits both an obese and a mild non-insulin-dependent
diabetic phenotype. To test the hypothesis that correction of the obese …

Glucocorticoids are important hormones in the regulation of metabolic homeostasis. We
infused normal rats with dexamethasone given intracerebroventricularly (icv) for 3 days. This …

Catecholamines are viewed as major stimulants of diet- and cold-induced thermogenesis
and of fasting-induced lipolysis, through the β-adrenoceptors (β 1 /β 2 /β 3 ). To test this …

A new member of the uncoupling protein (UCP) family called UCP3 has recently been
cloned and shown to be highly expressed in skeletal muscle of rodents and humans. In the …

Endurance exercise training has been shown to decrease diet‐induced thermogenesis (DIT)
in rats and humans. In rodents, most thermogenesis is thought to occur in brown adipose …