User profiles for Patrick P Michel

Patrick Pierre Michel

Senior PI, Paris Brain Institute -ICM, Paris
Verified email at icm-institute.org
Cited by 13478

Caspase-3: a vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease

A Hartmann, S Hunot, PP Michel… - Proceedings of the …, 2000 - National Acad Sciences
Caspase-3 is an effector of apoptosis in experimental models of Parkinson's disease (PD).
However, its potential role in the human pathology remains to be demonstrated. Using …

Nuclear translocation of NF-κB is increased in dopaminergic neurons of patients with Parkinson disease

…, B Brugg, D Ricard, PP Michel… - Proceedings of the …, 1997 - National Acad Sciences
Evidence from postmortem studies suggest an involvement of oxidative stress in the degeneration
of dopaminergic neurons in Parkinson disease (PD) that have recently been shown to …

[PDF][PDF] Understanding dopaminergic cell death pathways in Parkinson disease

PP Michel, EC Hirsch, S Hunot - Neuron, 2016 - cell.com
Parkinson disease (PD) is a multifactorial neurodegenerative disorder, the etiology of which
remains largely unknown. Progressive impairment of voluntary motor control, which …

Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats

…, PP Michel, K Parain, P Champy… - Journal of …, 2003 - Wiley Online Library
In Parkinson's disease, nigral dopaminergic neurones degenerate, whereas post‐synaptic
striatal target neurones are spared. In some atypical parkinsonian syndromes, both nigral and …

Dysfunction of mitochondrial complex I and the proteasome: interactions between two biochemical deficits in a cellular model of Parkinson's disease

GU Höglinger, G Carrard, PP Michel… - Journal of …, 2003 - Wiley Online Library
Two biochemical deficits have been described in the substantia nigra in Parkinson's disease,
decreased activity of mitochondrial complex I and reduced proteasomal activity. We …

The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease

…, C Depboylu, C Rouaux, PP Michel… - Proceedings of the …, 2007 - National Acad Sciences
The mechanisms leading to degeneration of dopaminergic neurons (DNs) in the substantia
nigra of patients with Parkinson's disease (PD) are not completely understood. Here, we …

Annonacin, a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical parkinsonism in …

…, F Medja, A Lombès, PP Michel… - Journal of …, 2004 - Wiley Online Library
In Guadeloupe, epidemiological data have linked atypical parkinsonism with fruit and herbal
teas from plants of the Annonaceae family, particularly Annona muricata. These plants …

The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy

…, A Lannuzel, ME Khondiker, PP Michel… - Journal of …, 2005 - Wiley Online Library
Reduced activity of the mitochondrial respiratory chain – particularly complex I – may be
implicated in the etiology of both Parkinson's disease and progressive supranuclear palsy, …

Annonacin, a natural mitochondrial complex I inhibitor, causes tau pathology in cultured neurons

…, EC Hirsch, WH Oertel, R Jacob, PP Michel… - Journal of …, 2007 - Soc Neuroscience
A neurodegenerative tauopathy endemic to the Caribbean island of Guadeloupe has been
associated with the consumption of anonaceous plants that contain acetogenins, potent …

[HTML][HTML] Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease

…, C Henze, C Depboylu, D Skrzydelski, PP Michel… - Scientific reports, 2013 - nature.com
In mammalians, toll-like receptors (TLR) signal-transduction pathways induce the expression
of a variety of immune-response genes, including inflammatory cytokines. It is therefore …