User profiles for Patrick P Michel
Patrick Pierre MichelSenior PI, Paris Brain Institute -ICM, Paris Verified email at icm-institute.org Cited by 13478 |
Caspase-3: a vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease
Caspase-3 is an effector of apoptosis in experimental models of Parkinson's disease (PD).
However, its potential role in the human pathology remains to be demonstrated. Using …
However, its potential role in the human pathology remains to be demonstrated. Using …
Nuclear translocation of NF-κB is increased in dopaminergic neurons of patients with Parkinson disease
Evidence from postmortem studies suggest an involvement of oxidative stress in the degeneration
of dopaminergic neurons in Parkinson disease (PD) that have recently been shown to …
of dopaminergic neurons in Parkinson disease (PD) that have recently been shown to …
[PDF][PDF] Understanding dopaminergic cell death pathways in Parkinson disease
Parkinson disease (PD) is a multifactorial neurodegenerative disorder, the etiology of which
remains largely unknown. Progressive impairment of voluntary motor control, which …
remains largely unknown. Progressive impairment of voluntary motor control, which …
Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats
…, PP Michel, K Parain, P Champy… - Journal of …, 2003 - Wiley Online Library
In Parkinson's disease, nigral dopaminergic neurones degenerate, whereas post‐synaptic
striatal target neurones are spared. In some atypical parkinsonian syndromes, both nigral and …
striatal target neurones are spared. In some atypical parkinsonian syndromes, both nigral and …
Dysfunction of mitochondrial complex I and the proteasome: interactions between two biochemical deficits in a cellular model of Parkinson's disease
GU Höglinger, G Carrard, PP Michel… - Journal of …, 2003 - Wiley Online Library
Two biochemical deficits have been described in the substantia nigra in Parkinson's disease,
decreased activity of mitochondrial complex I and reduced proteasomal activity. We …
decreased activity of mitochondrial complex I and reduced proteasomal activity. We …
The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease
…, C Depboylu, C Rouaux, PP Michel… - Proceedings of the …, 2007 - National Acad Sciences
The mechanisms leading to degeneration of dopaminergic neurons (DNs) in the substantia
nigra of patients with Parkinson's disease (PD) are not completely understood. Here, we …
nigra of patients with Parkinson's disease (PD) are not completely understood. Here, we …
Annonacin, a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical parkinsonism in …
…, F Medja, A Lombès, PP Michel… - Journal of …, 2004 - Wiley Online Library
In Guadeloupe, epidemiological data have linked atypical parkinsonism with fruit and herbal
teas from plants of the Annonaceae family, particularly Annona muricata. These plants …
teas from plants of the Annonaceae family, particularly Annona muricata. These plants …
The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy
…, A Lannuzel, ME Khondiker, PP Michel… - Journal of …, 2005 - Wiley Online Library
Reduced activity of the mitochondrial respiratory chain – particularly complex I – may be
implicated in the etiology of both Parkinson's disease and progressive supranuclear palsy, …
implicated in the etiology of both Parkinson's disease and progressive supranuclear palsy, …
Annonacin, a natural mitochondrial complex I inhibitor, causes tau pathology in cultured neurons
A neurodegenerative tauopathy endemic to the Caribbean island of Guadeloupe has been
associated with the consumption of anonaceous plants that contain acetogenins, potent …
associated with the consumption of anonaceous plants that contain acetogenins, potent …
[HTML][HTML] Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease
…, C Henze, C Depboylu, D Skrzydelski, PP Michel… - Scientific reports, 2013 - nature.com
In mammalians, toll-like receptors (TLR) signal-transduction pathways induce the expression
of a variety of immune-response genes, including inflammatory cytokines. It is therefore …
of a variety of immune-response genes, including inflammatory cytokines. It is therefore …