The mechanisms by which circadian pacemaker systems transmit timing information to control
behavior are largely unknown. Here, we define two critical features of that mechanism in …

Recent genetic analyses in worms, flies, and mammals illustrate the importance of bioactive
peptides in controlling numerous complex behaviors, such as feeding and circadian …

mef2 encodes the only apparent Drosophila homolog of the vertebrate myocyte-specific
enhancer factor 2 (MEF2). We show herein that the Drosophila MEF2 protein is expressed …

The neuropeptide Pigment-Dispersing Factor (PDF) is a principle transmitter regulating
circadian locomotor rhythms in Drosophila. We have identified a Class II (secretin-related) G …

In Drosophila, the neuropeptide pigment-dispersing factor (PDF) is required to maintain
behavioral rhythms under constant conditions. To understand how PDF exerts its influence, we …

The neuropeptide PDF is released by sixteen clock neurons in Drosophila and helps maintain
circadian activity rhythms by coordinating a network of ∼150 neuronal clocks. Whether …

Molecular genetics has revealed the identities of several components of the fundamental
circadian molecular oscillator — an evolutionarily conserved molecular mechanism of …

Neuropeptides modulate neural circuits controlling adaptive animal behaviors and physiological
processes, such as feeding/metabolism, reproductive behaviors, circadian rhythms, …

In the brain of the fly Drosophila melanogaster, ∼150 clock‐neurons are organized to
synchronize and maintain behavioral rhythms, but the physiological and neurochemical bases of …

The bHLH transcription factor DIMMED has been associated with the differentiation of
peptidergic cells in Drosophila. However, whether all Drosophila peptidergic cells express DIMM, …