To investigate the function of prostaglandin H synthase-1 and synthase-2 (PGHS-1 and
PGHS-2) in the normal lung and in allergic lung responses, we examined allergen-induced …

Historically, there has been intense interest in P450 metabolic oxidation, peroxidation, and
reduction of xenobiotics. More recently, there has been a growing appreciation for the role of …

Bacterial lipopolysaccharide (LPS) is a risk factor for exacerbation of asthma and causes
airway inflammation. The aim of this study was to examine the effects of disruption of …

A cDNA encoding a new cytochrome P450 was isolated from a mouse liver library. Sequence
analysis reveals that this 1,886-base pair cDNA encodes a 501-amino acid polypeptide …

The family of aspartic proteinases includes several human enzymes that may play roles in
both physiological and pathophysiological processes. The human lysosomal aspartic …

Interest in the active site specificity of human cathepsin D stems from the search for specific
therapeutic agents against many of the sequentially and structurally homologous members …

Alterations in nutritional status affect hepatic cytochrome P450 levels. Since cytochromes
P450 participate in the metabolism of arachidonic acid, we hypothesized that changes in liver …

Kinetic constants (K m ,k cat ) are derived for the hydrolysis of a number of chromogenic peptide
substrates by the aspartic proteinase from HIV-2. The effect of systematic replacement of …

The first crystal structures of members of the aspartic proteinase family were discussed at the
1976 Conference in Norman, Oklahoma [1]. Since that time, an increasingly rapid stream of …

Synthetic peptides are used for many purposes in chemistry and biology. Among these, one
of the most profitable has been the exploration of the specificity of proteolytic enzymes …