[HTML][HTML] Uncoupling of M1 muscarinic receptor/G-protein interaction by amyloid β1–42

H Janíčková, V Rudajev, P Zimčík, J Jakubík… - …, 2013 - Elsevier
The overproduction of β-amyloid (Aβ) fragments in transgenic APPswe/PS1dE9 mice results
in formation of amyloid deposits in the cerebral cortex and hippocampus starting around …

[HTML][HTML] Applications and limitations of fitting of the operational model to determine relative efficacies of agonists

J Jakubík, A Randáková, V Rudajev, P Zimčík… - Scientific reports, 2019 - nature.com
Proper determination of agonist efficacy is essential in the assessment of agonist selectivity
and signalling bias. Agonist efficacy is a relative term that is dependent on the system in …

Apolipoprotein E4 reduces evoked hippocampal acetylcholine release in adult mice

E Dolejší, O Liraz, V Rudajev, P Zimčík… - Journal of …, 2016 - Wiley Online Library
Apolipoprotein E4 (apoE4) is the most prevalent genetic risk factor for Alzheimer's disease.
We utilized apoE4‐targeted replacement mice (approved by the Tel Aviv University Animal …

Molecular mechanisms of methoctramine binding and selectivity at muscarinic acetylcholine receptors

J Jakubík, P Zimčík, A Randáková, K Fuksová… - Molecular …, 2014 - ASPET
Methoctramine (N,N'-bis[6-[[(2-methoxyphenyl)-methyl]hexyl]-1,8-octane] diamine) is an M 2
-selective competitive antagonist of muscarinic acetylcholine receptors and exhibits …

[HTML][HTML] Binding of N-methylscopolamine to the extracellular domain of muscarinic acetylcholine receptors

J Jakubík, A Randáková, P Zimčík, EE El-Fakahany… - Scientific reports, 2017 - nature.com
Interaction of orthosteric ligands with extracellular domain was described at several aminergic
G protein-coupled receptors, including muscarinic acetylcholine receptors. The orthosteric …

[HTML][HTML] Classical and atypical agonists activate M1 muscarinic acetylcholine receptors through common mechanisms

A Randáková, E Dolejší, V Rudajev, P Zimčík… - Pharmacological …, 2015 - Elsevier
We mutated key amino acids of the human variant of the M 1 muscarinic receptor that target
ligand binding, receptor activation, and receptor-G protein interaction. We compared the …

[HTML][HTML] Role of membrane cholesterol in differential sensitivity of muscarinic receptor subtypes to persistently bound xanomeline

A Randáková, E Dolejší, V Rudajev, P Zimčík… - …, 2018 - Elsevier
Xanomeline (3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole) is a
muscarinic agonist that is considered to be functionally selective for the M 1 /M 4 receptor …

[HTML][HTML] Fusion with Promiscuous Gα16 Subunit Reveals Signaling Bias at Muscarinic Receptors

…, D Nelic, M Hochmalová, P Zimčík… - International Journal of …, 2021 - mdpi.com
A complex evaluation of agonist bias at G-protein coupled receptors at the level of G-protein
classes and isoforms including non-preferential ones is essential for advanced agonist …

Selected ion flow tube mass spectrometry, SIFT-MS

K Sovová - 2014 - dspace.cuni.cz
… Finally, I would like to thank Pavel Zimčík, all my friends and family members, especially
my parents for their kind support and encouragement. …

[PDF][PDF] Distributions of vascular plants in the Czech Republic. Part 8

Z Kaplan, J Danihelka, J Chrtek Jr, J Zazvorka… - Preslia, 2019 - is.muni.cz
Integration of all available records on the distribution of vascular plants in the Czech Republic
into a single central database and initiation of mapping their distributions were two of the …