Elevated rates of reactive oxygen species (ROS) have been detected in almost all cancers,
where they promote many aspects of tumour development and progression. However, …

1. Abstract 2. Introduction 3. Reactive oxygen species in tumor growth and cellular survival 4.
Reactive oxygen species in cell motility and metastasis formation 5. Generation of reactive …

Initiation of pancreatic ductal adenocarcinoma (PDA) is definitively linked to activating
mutations in the KRAS oncogene. However, PDA mouse models show that mutant Kras …

Tumor necrosis factor (TNF‐alpha) stimulates a number of signal transduction pathways in
which phospholipases produce lipid second messengers. However, the immediate molecular …

The activation of the transcription factor NF-κB is critical for a number of physiological
responses. Here, we provide evidence for a signaling pathway that mediates NF-κB activation in …

Selection of target substrates by protein kinases is strongly influenced by the amino acid
sequence surrounding the phosphoacceptor site. Identification of the preferred peptide …

The ε4 allele of the apolipoprotein E (APOE) gene, a genetic risk factor for Alzheimer’s disease,
is abundantly expressed in both the brain and periphery. Here, we present evidence that …

Protein kinase D (PKD) regulates the fission of vesicles originating from the trans-Golgi
network 1 , 2 . We show that phosphatidylinositol 4-kinase IIIβ (PI4KIIIβ) — a key player in the …

Reactive oxygen species (ROS) and cellular oxidative stress are involved in many physiological
and pathophysiological processes, including cellular and organismal aging, migration, …

Acinar cells in the adult pancreas show high plasticity and can undergo transdifferentiation
to a progenitor-like cell type with ductal characteristics. This process, termed acinar-to-ductal …