Evolving organic synthesis fostered by the pluripotent phenylsulfone moiety

…, MN Noshi, XM du Jourdin, PL Fuchs - Chemical reviews, 2009 - ACS Publications
… In 2003, he joined the research group of Professor Philip L. Fuchs at Purdue University
where he is currently completing his Ph.D. His research is focused on the synthesis of …

Design and Synthesis of [111In]DTPA−Folate for Use as a Tumor-Targeted Radiopharmaceutical

…, CJ Mathias, MA Green, PL Fuchs… - Bioconjugate …, 1997 - ACS Publications
Folate-conjugated metal chelates have been proposed as potential imaging agents for cancers
that overexpress folate receptors. In a previous study, folic acid was linked through its γ-…

Chlorosulfenylation-dehydrochlorination reactions. New and improved methodology for the synthesis of unsaturated aryl sulfides and aryl sulfones

PB Hopkins, PL Fuchs - The Journal of Organic Chemistry, 1978 - ACS Publications
An improved procedure has been developed for the chlorosulfenylation of olefins. The
method utilized is based on the quantitative reaction of aryl thiols with iV-chlorosuccinimide to …

Conversion of cyclic vinyl sulfones to transposed vinyl phosphonates

…, A El-Awa, E Torres, PL Fuchs - Journal of the American …, 2007 - ACS Publications
Functionalized cyclic vinyl sulfones were directly converted to the “polarity reversed” vinyl
phosphonates through an efficient one pot procedure. Ozonolysis of these vinyl sulfones and …

Chemistry of trisdecacyclic pyrazine antineoplastics: The cephalostatins and ritterazines

S Lee, TG LaCour, PL Fuchs - Chemical reviews, 2009 - ACS Publications
The search for natural products of medicinal significance led the Pettit group to isolate the
cephalostatins1 (from the hemichordate worm Cephalodiscus gilchristi, 2 eg, cephalostatin 1 (1…

A Concise Total Synthesis of dl-Histrionicotoxin

…, ML Alcaraz, RA Stockman, PL Fuchs - Journal of the …, 2006 - ACS Publications
The synthesis of (±)-histrionicotoxin has been achieved in just nine steps using a two-directional
synthesis strategy. Key reactions include a two-directional cross-metathesis, a tandem …

[BOOK][B] Reagents for silicon-mediated organic synthesis

PL Fuchs - 2011 - books.google.com
Over the last three decades the importance of organosilicon chemistry has greatly increased
because it has opened a number of new synthetic strategies. Silicon reagents are usually …

Phosphorus betaines derived from cycloheptene and cyclooctene oxides. Inversion of cyclooctene

E Vedejs, KAJ Snoble, PL Fuchs - The Journal of Organic …, 1973 - ACS Publications
trans-Cyclooctene, irtms-l-methylcyclooctene, ct's, irtms-1, 4-cyclooctadiene, and c» 8, irons-l,
o-cyclooctadiene can be prepared from the corresponding epoxides by treatment with …

Reduction of Azides to Primary Amines in Substrates Bearing Labile Ester Functionality. Synthesis of a PEG-Solubilized,“Y”-Shaped Iminodiacetic Acid Reagent for …

JW Lee, PL Fuchs - Organic Letters, 1999 - ACS Publications
Anhydride 3 is a useful reagent for the synthesis of triply linked drug conjugates. Examples
using paclitaxel are provided. Conversion of the azido moiety to a primary amine in the …

3,3,3-Trichloropropyl-1-triphenylphosphorane:  A Reagent for the Synthesis of (Z)-1,3-Enynes, (Z,Z)-1-Chloro-1,3-dienes, and 1,3-Diynes

MS Karatholuvhu, PL Fuchs - Journal of the American Chemical …, 2004 - ACS Publications
3,3,3-Trichloropropyl-1-triphenylphosphonium chloride is conveniently prepared from 2-chloroethanol,
triphenylphosphine, and trichloroacetic acid. Deprotonation of this reagent …