Secretory phospholipases A 2 (sPLA 2 ) are structurally related enzymes found in mammals
as well as in insect and snake venoms. They have been associated with several …

… November 17, 1993) These high levels of msPLA,s have often been associated with
Wrard Lambeau, Philippe Ancian, high levels of tumor necrosis factor and/or interleukin-1. …

The potential of the minipig as a platform for future developments in genomics, high density
biology, transgenic technology, in vitro toxicology and related emerging technologies was …

Revised Manuscript Received August 14, 1995® abstract: M-type (180 kDa) receptors for
secretory phospholipases A2 (SPLA2S) are thought to mediate some of the physiological …

Objective Colony‐stimulating factor 1 receptor (CSF‐1R) essentially modulates monocyte
proliferation, migration, and activation, which are considered important for the pathogenesis of …

Specific membrane receptors for secretory phospholipases A 2 (sPLA 2 s) have been initially
identified with novel snake venom sPLA 2 s called OS 1 and OS 2 . One of these sPLA 2 …

Retinoic acids are morphogenic signaling molecules that are derived from vitamin A and
involved in a variety of tissue functions. Two groups of their nuclear receptors have been …

Lenadogene nolparvovec (Lumevoq) gene therapy was developed to treat Leber hereditary
optic neuropathy (LHON) caused by the m.11778G > A in MT-ND4 that affects complex I of …

Cancer progression has been associated with the presence of tumor-associated M2-macrophages
(M2-TAMs) able to inhibit anti-tumor immune responses. It is also often associated …

There is a growing need to consider non-rodent species for the immunological safety
evaluation of drug candidates. The EU Framework-6 RETHINK Project demonstrated that the …