Rheumatoid arthritis–associated (RA-associated) inflammation is mediated through the
interaction between RA IgG immune complexes and IgG Fc receptors on immune cells. …

A favorable outcome following acute bacterial infection depends on the ability of phagocytic
cells to be recruited and properly activated within injured tissues. Calcium (Ca 2+) is a …

Ischemia–reperfusion injury (IRI) is an important cause of acute kidney injury that can lead
to end-stage renal failure. Although the ensuing inflammatory response can restore …

Free ADP-ribose (ADPR), a product of NAD hydrolysis and a breakdown product of the
calcium-release second messenger cyclic ADPR (cADPR), has no defined role as an intracellular …

Calcium-activated nonselective (CAN) cation channels are expressed in various excitable
and nonexcitable cells supporting important cellular responses such as neuronal bursting …

Serum IgA is considered a discrete housekeeper of the immune system with multiple anti-inflammatory
functions, whereas IgA-immune complexes mediate inflammatory responses. …

TRPM4 has recently been described as a calcium-activated nonselective (CAN) cation channel
that mediates membrane depolarization. However, the functional importance of TRPM4 …

The pathogenesis of immunoglobulin A (IgA) nephropathy (IgAN), the most prevalent form
of glomerulonephritis worldwide, involves circulating macromolecular IgA1 complexes. …

Hematopoiesis occurs in distinct waves. "Definitive" hematopoietic stem cells (HSCs) with
the potential for all blood lineages emerge in the aorta-gonado-mesonephros, while "primitive" …

Dendritic cell (DC) maturation and migration are events critical for the initiation of immune
responses. After encountering pathogens, DCs upregulate the expression of costimulatory …