Clopidogrel (SR25990C, PLAVIX) is a potent antiplatelet drug, which has been recently
launched and is indicated for the prevention of vascular thrombotic events in patients at risk. …

The growth arrest-specific gene 6 product (Gas6) is a secreted protein related to the anticoagulant
protein S but its role in hemostasis is unknown. Here we show that inactivation of the …

Neuropilin 2 (NRP2) is a receptor for the vascular endothelial growth factor (VEGF) and the
semaphorin (SEMA) families, 2 unrelated ligand families involved in angiogenesis and …

Ticlopidine and clopidogrel belong to the same chemical family of thienopyridine adenosine
diphosphate (ADP)-receptor antagonists. They have shown their efficacy as platelet …

P2Y12, a G protein-coupled receptor that plays a central role in platelet activation has been
recently identified as the receptor targeted by the antithrombotic drug, clopidogrel. In this …

Mechanisms regulating thrombus stabilization remain largely unknown. Here, we report that
loss of any 1 of the Gas6 receptors (Gas6-Rs), ie, Tyro3, Axl, or Mer, or delivery of a soluble …

HLA-G is a major histocompatibility complex class Ib molecule whose constitutive tissue
distribution is restricted mainly to trophoblast cells at the maternal-fetal interface during …

The P2Y 13 receptor has recently been identified as a new P2Y receptor sharing a high
sequence homology with the P2Y 12 receptor as well as similar functional properties: coupling …

The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered
member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report …

Patients suffering a transient ischaemic attack (TIA) or ischaemic stroke (IS) have a high risk
of recurrence. The inhibition of platelet function is effective in the reduction of secondary …