Elucidating the key signal transduction pathways essential for both antipsychotic efficacy
and side-effect profiles is essential for developing safer and more effective therapies. Recent …

Stress and anxiety disorders are risk factors for depression and these behaviors are modulated
by corticotrophin-releasing factor receptor 1 (CRFR1) and serotonin receptor (5-HT 2 R). …

The diarylheptanoid 7-(4′-hydroxy-3′-methoxyphenyl)-1-phenylhept-4-en-3-one (HMP)
is a naturally occurring phytochemical found in lesser galangal (Alpinia officinarum). In the …

Here, we describe a newly generated transgenic mouse in which the Gs DREADD (rM3Ds),
an engineered G protein-coupled receptor, is selectively expressed in striatopallidal medium …

Drug-induced valvular heart disease (VHD) is a serious side effect of a few medications,
including some that are on the market. Pharmacological studies of VHD-associated medications …

Here, we report that postsynaptic density protein of 95 kDa (PSD-95), a postsynaptic density
scaffolding protein, classically conceptualized as being essential for the regulation of …

G protein–coupled receptors (GPCRs) exhibit highly conserved activation and signaling
mechanisms by which agonist stimulation leads to coupling of heterotrimeric G proteins and …

Dysregulation of the 5-HT 2A receptor is implicated in both the etiology and treatment of
schizophrenia. Although the essential role of 5-HT 2A receptors in atypical antipsychotic drug …

Four series of structurally related β-lactams, 2,5-pyrrolidinediones, azaspirodecatrienediones
(ASDT) and dihydropyrroloquinoxalinetriones (DPQT) were synthesized by utilizing post-…

GPR40 (Free fatty acid receptor 1) has emerged as an important therapeutic target for diabetes.
Several studies have demonstrated the association of comorbid psychiatric conditions …