User profiles for Priti Kumar
Priti KumarAssociate Professor of Internal Medicine, Yale University Verified email at yale.edu Cited by 10652 |
Transvascular delivery of small interfering RNA to the central nervous system
A major impediment in the treatment of neurological diseases is the presence of the blood–brain
barrier, which precludes the entry of therapeutic molecules from blood to brain. Here we …
barrier, which precludes the entry of therapeutic molecules from blood to brain. Here we …
[HTML][HTML] T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice
Evaluation of the therapeutic potential of RNAi for HIV infection has been hampered by the
challenges of siRNA delivery and lack of suitable animal models. Using a delivery method for …
challenges of siRNA delivery and lack of suitable animal models. Using a delivery method for …
Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations
Despite antiretroviral therapy (ART), human immunodeficiency virus (HIV)-1 persists in a
stable latent reservoir 1 , 2 , primarily in resting memory CD4 + T cells 3 , 4 . This reservoir …
stable latent reservoir 1 , 2 , primarily in resting memory CD4 + T cells 3 , 4 . This reservoir …
[PDF][PDF] Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy
Neutralizing antibodies (NAbs) are effective in treating COVID-19, but the mechanism of
immune protection is not fully understood. Here, we applied live bioluminescence imaging (BLI) …
immune protection is not fully understood. Here, we applied live bioluminescence imaging (BLI) …
Analysis of cell viability by the MTT assay
P Kumar, A Nagarajan… - Cold spring harbor …, 2018 - cshprotocols.cshlp.org
Among viability assays that depend on the conversion of substrate to chromogenic product
by live cells, the MTT assay is still among one of the most versatile and popular assays. The …
by live cells, the MTT assay is still among one of the most versatile and popular assays. The …
[HTML][HTML] miRNA profiling of naive, effector and memory CD8 T cells
microRNAs have recently emerged as master regulators of gene expression during
development and cell differentiation. Although profound changes in gene expression also occur …
development and cell differentiation. Although profound changes in gene expression also occur …
Analysis of cell viability by the lactate dehydrogenase assay
P Kumar, A Nagarajan… - Cold Spring Harbor …, 2018 - cshprotocols.cshlp.org
A common method for determining cytotoxicity is based on measuring the activity of
cytoplasmic enzymes released by damaged cells. Lactate dehydrogenase (LDH) is a stable …
cytoplasmic enzymes released by damaged cells. Lactate dehydrogenase (LDH) is a stable …
Exploring single-cell data with deep multitasking neural networks
…, M Venkataswamy, A Desai, V Ravi, P Kumar… - Nature …, 2019 - nature.com
It is currently challenging to analyze single-cell data consisting of many cells and samples,
and to address variations arising from batch effects and different sample preparations. For …
and to address variations arising from batch effects and different sample preparations. For …
[PDF][PDF] A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection
Emerging evidence indicates that both neutralizing and Fc-mediated effector functions of
antibodies contribute to protection against SARS-CoV-2. It is unclear whether Fc-effector …
antibodies contribute to protection against SARS-CoV-2. It is unclear whether Fc-effector …
[HTML][HTML] RNAi-mediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice
RNA interference (RNAi)–mediated knockdown of gene expression offers a novel treatment
strategy for human immunodeficiency virus (HIV) infection. However, the major hurdle for …
strategy for human immunodeficiency virus (HIV) infection. However, the major hurdle for …