ATPase activity associated with P-glycoprotein (Pgp) is characterized by three drug-dependent
phases: basal (no drug), drug-activated, and drug-inhibited. To understand the …

OBJECTIVE To determine the mechanisms by which blockade of adenosine A 2B receptors
(A 2B Rs) reduces insulin resistance. RESEARCH DESIGN AND METHODS We …

The endogenous purine nucleoside adenosine is an important antiinflammatory mediator
that contributes to the control of CD4+ T cell responses. While adenosine clearly has direct …

A barrier to drug development for nonalcoholic steatohepatitis (NASH) is the absence of
translational preclinical human-relevant systems. An in vitro liver model was engineered to …

Background and purpose: The adenosine 2B (A 2B ) receptor is the predominant adenosine
receptor expressed in the colon. Acting through the A 2B receptor, adenosine mediates …

Introduction: Drug induced steatohepatitis (DISH), a form of drug induced liver injury (DILI)
is characterized by intracellular accumulation of lipids in hepatocytes and subsequent …

Background & Aims Increasing evidence highlights dietary fructose as a major driver of non-alcoholic
fatty liver disease (NAFLD) pathogenesis, the majority of which is cleared on first …

Helicobacter pylori causes a lifelong infection and provides a model of bacterial adaptation
and persistent colonization. Adenosine is an anti-inflammatory mediator that limits tissue …

Utilizing human P-glycoprotein (P-gp), we investigated methods to enhance the heterologous
expression of ATP-binding cassette transporters in Saccharomyces cerevisiae. Human …

Background: A short-term protocol for evaluation of National Football League (NFL) athletes
incurring concussion has yet to be fully defined and framed in the context of the short-term …