User profiles for R A Mumford

Rick Mumford

Head of Science, Evidence & Research, UK Food Standards Agency
Verified email at food.gov.uk
Cited by 4454

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

…, TD Lee, JE Shively, M MacCross, RA Mumford… - Nature, 1992 - nature.com
Interleukin-1β (IL-1β)-converting enzyme cleaves the IL-1β precursor to mature IL-1β, an
important mediator of inflammation. The identification of the enzyme as a unique cysteine …

Cloning and characterization of inducible nitric oxide synthase from mouse macrophages

Q Xie, HJ Cho, J Calaycay, RA Mumford, KM Swiderek… - Science, 1992 - science.org
… Calaycay and RA Mumford, Department of Biochemical and Molecular Pathology, Merck
Sharpe & Dohme Research Laboratories, Rahway, NJ 07065. KM Swiderek and TD Lee, …

Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin

…, CD Bennett, E Rands, RE Diehl, RA Mumford… - Nature, 1986 - nature.com
The adenylate cyclase system, which consists of a catalytic moiety and regulatory guanine
nucleotide-binding proteins, provides the effector mechanism for the intracellular actions of …

Calmodulin is a subunit of nitric oxide synthase from macrophages.

HJ Cho, QW Xie, J Calaycay, RA Mumford… - The Journal of …, 1992 - rupress.org
A central issue in nitric oxide (NO) research is to understand how NO can act in some
settings as a servoregulator and in others as a cytotoxin. To answer this, we have sought a …

Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints.

…, JR Weidner, HR Williams, RA Mumford… - The Journal of …, 1997 - Am Soc Clin Investig
… Both neoepitopes were also detected by immunohistochemistry in articular cartilage from
patients undergoing joint replacement for osteoarthritis (OA), rheumatoid arthritis (RA), and in …

Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease

II Singer, DW Kawka, S Scott, JR Weidner, RA Mumford… - Gastroenterology, 1996 - Elsevier
BACKGROUND & AIMS: Inducible nitric oxide synthase (iNOS) is generated in several cell
types by treatment with lipopolysaccharides or cytokines. Earlier studies suggested that …

IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha.

…, KA Hogquist, DD Chaplin, RA Mumford - … (Baltimore, Md.: 1950 …, 1991 - journals.aai.org
IL-1 converting enzyme (ICE) specifically cleaves the human IL-1 beta precursor at two
sequence-related sites: Asp27-Gly28 (site 1) and Asp116-Ala117 (site 2). Cleavage at Asp116-…

Detection of Potato mop top virus and Tobacco rattle virus Using a Multiplex Real-Time Fluorescent Reverse-Transcription Polymerase Chain Reaction Assay

RA Mumford, K Walsh, I Barker… - Phytopathology, 2000 - Am Phytopath Society
Tobacco rattle virus (TRV) and Potato mop top virus (PMTV) are important diseases of potato
that are difficult to diagnose reliably by visual symptoms. Effective control strategies rely on …

Development of a real-time RT-PCR assay for the detection of Potato spindle tuber viroid

…, A Blockley, K Walsh, I Barker, RA Mumford - Journal of virological …, 2004 - Elsevier
Potato spindle tuber viroid (PSTVd) is a quarantine pathogen in the European Union and
causes damaging diseases of solanaceous crops. Under the EU Plant Health directive 2000/29…

The biology of the tospoviruses

RA Mumford, I Barker, KR Wood - Annals of Applied Biology, 1996 - Wiley Online Library
The tospoviruses are a diverse, cosmopolitan and economically important genus of plant
viruses. In the recent past, interest in the tospoviruses has been rekindled with the resurgence …