Combination antiretroviral therapy (CART) has proven to effectively suppress systemic HIV
burden, however, poor penetration into the central nervous system (CNS) provides …

The strong repair and pro-survival functions of neurotrophins at their primary receptors, TrkA,
TrkB and TrkC, have made them attractive candidates for treatment of nervous system …

The choroid plexus is a multifunctional organ that sits at the interface between the blood
and cerebrospinal fluid (CSF). It serves as a gateway for immune cell trafficking into the CSF …

Although several recent anatomical and physiological studies indicate that glutamate receptors
are likely to play a role in the regulation of various hypothalamic functions, no attempt …

The initiating events that promote tau mislocalization and pathology in Alzheimer's disease (AD)
are not well defined, partly because of the lack of endogenous models that recapitulate …

Feline brain endothelial cells (BECs), astrocytes, and microglia were combined in different
configurations in a cell culture insert system to assess the effect of different cell types on the …

We recently discovered that (3α,5α)3-hydroxypregnan-20-one (allopregnanolone) inhibits
pro-inflammatory toll-like receptor (TLR) activation and cytokine/chemokine production in …

Highly active antiretroviral therapy (HAART) has revolutionized human immunodeficiency
virus (HIV) healthcare, turning it from a terminal to a potentially chronic disease, although …

Although Myo10 (myosin-X) is an unconventional myosin associated with filopodia, little is
known about its isoforms and roles in the nervous system. We report here that, in addition to …

To characterize the role of neurotrophin receptors on macrophages, we investigated the
ability of nerve growth factor (NGF) and its precursor, proNGF, to regulate human macrophage …