Solid manganese dioxide as an oxidizing agent

RJ Highet, WC Wildman - Journal of the American Chemical …, 1955 - ACS Publications
Solid manganese dioxide has been shown capable of oxidizing two benzyl alcohols to
benzaldehydes, three amines to the corresponding Schiff bases, an aldehyde-ammonia to a …

Mutagenic perylenequinone metabolites of Alternaria alternata: altertoxins I, II, and III

…, SW Page, AE Pohland, RJ Highet… - Journal of natural …, 1986 - ACS Publications
The mold genus Alternaría is a widely distributed plant pathogen. Some of these species, eg,
A. alternata, are common decay organisms of fruits and vegetables. Two novel perylene …

Sequential oxidation and glutathione addition to 1, 4-benzoquinone: correlation of toxicity with increased glutathione substitution.

SS Lau, BA Hill, RJ Highet, TJ Monks - Molecular pharmacology, 1988 - ASPET
The chemical reaction of 1,4-benzoquinone with glutathione results in the formation of adducts
that exhibit increasing degrees of glutathione substitution. Purification of these adducts …

Artemisinin: An Endoperoxidic Antimalarial from Artemisia annua L.

E Fattorusso, RJ Highet, DL Klayman… - Fortschritte der Chemie …, 1997 - Springer
For thousands of years, physicians in China have treated fever with a decoction of the plant
qinghao (1). In 1972 Chinese chemists isolated the active febrifuge from this plant, …

The chemistry of the antibiotics chrysomycin A and B Antitumor activity of chrysomycin A

U Weiss, K Yoshihira, RJ Highet, RJ White… - The Journal of …, 1982 - jstage.jst.go.jp
* This relationship between 1 and 2, while uncommon, is not unprecedented among pairs of
natural compounds; see, eg, the pyrethrins and cinerins. Other analogous, if less closely …

Occurrence of skin alkaloids in non-dendrobatid frogs from Brazil (Bufonidae), Australia (Myobatrachidae) and Madagascar (Mantellinae)

JW Daly, RJ Highet, CW Myers - Toxicon, 1984 - Elsevier
JW Daly, RJ Highet and CW Myers. Occurrence of skin alkaloids in non-dendrobatid frogs
from Brazil (Bufonidae), Australia (Myobatrachidae) and Madagascar (Mantellinae). Toxicon22…

Alkaloids from dendrobatid frogs: structures of two ω-hydroxy congeners of 3-butyl-5-propylindolizidine and occurrence of 2, 5-disubstituted pyrrolidines and a 2, 6 …

…, TF Spande, N Whittaker, RJ Highet… - Journal of natural …, 1986 - ACS Publications
Forty alkaloids were detected and characterized from skin extracts of high-and low-elevation
populations of the poison frog Dendrobates histrionicus from northwestern Colombia. …

Nuclear magnetic resonance spectra of flavonoids

TJ Batterham, RJ Highet - Australian Journal of Chemistry, 1964 - CSIRO Publishing
The nuclear magnetic resonance spectra of the aromatic, olefinic, and hydroxyl protons of 41
flavonoids have been examined. It is found that these spectra reveal the pattern of oxygen …

A new class of indolizidine alkaloids from the poison frog, Dendrobates tricolor. X-ray analysis of 8-hydroxy-8-methyl-6-(2'-methylhexylidene)-1-azabicyclo [4.3. 0] …

…, T Tokuyama, T Fujiwara, RJ Highet… - Journal of the …, 1980 - ACS Publications
The structure and absolute configuration of a unique alkaloid isolated from an Ecuadoran
frog, Dendrobates tri-color, havebeen elucidated by X-ray crystallography and found to be 8-…

Immunochemical detection of liver protein adducts of the nonsteroidal antiinflammatory drug diclofenac

…, TG Myers, JC Davila, RJ Highet… - Chemical research in …, 1993 - ACS Publications
Serious idiosyncratic hepatic injury has been associated with the use of many nonsteroidal
antiinflammatory drugs, including the widely prescribedagent diclofenac. In order to …