In the search for novel cancer therapies that can be used in conjunction with existing
treatments, one promising area of research is the use of viral vectors and whole viruses. This …

THE neurofibromatoses consist of two distinct disorders, 1 , 2 the genes for which have
recently been located on separate chromosomes. Neurofibromatosis 1, also called von …

It has been 9 years since the beginning of the first clinical trial in which an oncolytic virus
was administered to cancer patients. Since then, oncolytic viruses from five different species …

Human cancers are complex ecosystems composed of cells with distinct phenotypes, genotypes,
and epigenetic states, but current models do not adequately reflect tumor composition …

Neurofibromatosis 2 (NF2) is a dominantly inherited disorder characterized by the occurrence
of bilateral vestibular schwannomas and other central nervous system tumors including …

G207 is a conditionally replicating derivative of herpes simplex virus (HSV) type-1 strain F
engineered with deletions of both γ 1 34.5 loci and a lacZ insertion disabling the UL 39 gene. …

✓ The rates of survival, tumor recurrence, and tumor progression were analyzed in 225 patients
with meningioma who underwent surgery as the only treatment modality between 1962 …

Malignant gliomas are the most common malignant brain tumors and are almost always fatal.
A thymidine kinase-negative mutant of herpes simplex virus-1 (dlsptk) that is attenuated for …

We have created a double mutant of the herpes simplex virus (HSV) type 1 (termed G207)
with favourable properties for treating human malignant brain tumours: replication–…

Although human tumours are shaped by the genetic evolution of cancer cells, evidence also
suggests that they display hierarchies related to developmental pathways and epigenetic …