User profiles for R M Philpot
 | Rex M PhilpotUniversity of south florida Verified email at health.usf.edu Cited by 1003 |
Isoform specificity of trimethylamine N-oxygenation by human flavin-containing monooxygenase (FMO) and P450 enzymes: selective catalysis by FMO3
…, C Ibarra, R Gasser, K Itagaki, RM Philpot… - Biochemical …, 1998 - Elsevier
In the present study, we expressed human flavin-containing monooxygenase 1 (FMO1), FMO3,
FMO4t (truncated), and FMO5 in the baculovirus expression vector system at levels of 0.6 …
FMO4t (truncated), and FMO5 in the baculovirus expression vector system at levels of 0.6 …
A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities
…, T Kimura, J Ozols, IR Phillips, RM Philpot… - Archives of Biochemistry …, 1994 - Elsevier
A nomenclature based on comparisons of amino acid sequences is proposed for the
members of the mammalian flavin-containing monooxygenase (FMO) gene family. This …
members of the mammalian flavin-containing monooxygenase (FMO) gene family. This …
Interaction of methylenedioxyphenyl (1, 3-benzodioxole) compounds with enzymes and their effects on mammals
E Hodgson, RM Philpot - Drug metabolism reviews, 1975 - Taylor & Francis
… achieved with an in vitro system by Philpot and Hodgson [92]. … [l69] using mouse liver
microsomes and by Philpot and Hodgson … Preliminary experiments by Philpot and Hodgson [92] …
microsomes and by Philpot and Hodgson … Preliminary experiments by Philpot and Hodgson [92] …
Quantitation and kinetic properties of hepatic microsomal and recombinant flavin-containing monooxygenases 3 and 5 from humans
LH Overby, GC Carver, RM Philpot - Chemico-biological interactions, 1997 - Elsevier
Variable amounts of flavin-containing monooxygenase isoforms 3 and 5 (FMO3 and FMO5)
are present in microsomal preparations from adult, male, human liver. Quantitation with …
are present in microsomal preparations from adult, male, human liver. Quantitation with …
Place conditioning: age‐related changes in the rewarding and aversive effects of alcohol
RM Philpot, KA Badanich… - Alcoholism: clinical and …, 2003 - Wiley Online Library
Background: Alcohol abuse levels are very high in adolescents, creating a significant societal
issue. It has been shown that people who begin alcohol use as adolescents are more …
issue. It has been shown that people who begin alcohol use as adolescents are more …
Repeated ethanol exposure during adolescence alters the developmental trajectory of dopaminergic output from the nucleus accumbens septi
… to the HPLC methodology used in the study by Philpot and Kirstein (2004), which may have
… Philpot conducted all experiments. Drs. Wecker and Philpot analyzed the data, constructed …
… Philpot conducted all experiments. Drs. Wecker and Philpot analyzed the data, constructed …
The mammalian flavin-containing monooxygenases: molecular characterization and regulation of expression
RN Hines, JR Cashman, RM Philpot… - Toxicology and applied …, 1994 - Elsevier
The flavin-containing monooxygenase (FMO) has been characterized in several mammalian
species, including human. The FMO forms a stable NADP(H)− and oxygen-dependent 4α-…
species, including human. The FMO forms a stable NADP(H)− and oxygen-dependent 4α-…
Expression of truncated forms of liver microsomal P450 cytochromes 2B4 and 2E1 in Escherichia coli: influence of NH2-terminal region on localization in cytosol and …
…, JR Larson, RM Philpot… - Proceedings of the …, 1993 - National Acad Sciences
The currently accepted model for the membrane topology of microsomal cytochrome P450 is
that of a largely cytoplasmic domain bound by only one or two transmembrane segments at …
that of a largely cytoplasmic domain bound by only one or two transmembrane segments at …
[HTML][HTML] An open-label pilot trial of minocycline in children as a treatment for Angelman syndrome
…, MR Schoenberg, AG Smith, RM Philpot… - BMC neurology, 2014 - Springer
Background Minocycline, a member of the tetracycline family, has a low risk of adverse effects
and an ability to improve behavioral performance in humans with cognitive disruption. We …
and an ability to improve behavioral performance in humans with cognitive disruption. We …
Metabolic activation of 4-ipomeanol by complementary DNA-expressed human cytochromes P-450: evidence for species-specific metabolism
M Czerwinski, TL McLemore, RM Philpot… - Cancer research, 1991 - AACR
4-Ipomeanol is a pulmonary toxin in cattle and rodents that is metabolically activated by
cytochromes P-450 (P-450s). P-450-mediated activation of 4-ipomeanol to DNA binding …
cytochromes P-450 (P-450s). P-450-mediated activation of 4-ipomeanol to DNA binding …