L-asparaginase and L-asparagine metabolism

DA Cooney, RE Handschumacher - Annual review of …, 1970 - annualreviews.org
Since most clinical studies employ the enzyme from E. coli, its properties will be reviewed in
some detail. The specific activity of the best preparations has varied between 300 and 625 …

[HTML][HTML] Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update

…, RL Russell, D Zhang, RE Handschumacher - … et Biophysica Acta (BBA …, 2002 - Elsevier
… In a murine model, hepatic UPase has been found to follow a circadian rhythm which was
the inverse of that for plasma uridine concentration, re-emphasizing its role in the regulation of …

Cyclophilin: a specific cytosolic binding protein for cyclosporin A

RE Handschumacher, MW Harding, J Rice, RJ Drugge… - Science, 1984 - science.org
… Ampholytes were removed by increasing the ionic strength to l.OM phosphate, followed by
adsorption onto a 1 by 30 cm phenyl Sepharose CL4B column (Pharmacia). Cyclophilin ac…

L-asparaginase

…, JR Bertino, RE Handschumacher - Annual review of …, 1970 - annualreviews.org
The development of L-asparaginase as a therapeutic agent began in _953 when Kidd (1, 2)
reported that the growth of certain neoplasms in mice Lnd rats was inhibited by guinea pig …

[HTML][HTML] Leukocyte chemotactic activity of cyclophilin.

…, MC Leiva, SA Fischkoff, RE Handschumacher… - Journal of Biological …, 1992 - Elsevier
During the purification of eosinophil chemotactic factors synthesized by the uterus in
response to estrogen we isolated a protein having an N-terminal (15 amino acids) sequence …

L-Asparaginase: Clinical, Biochemical, Pharmacological, and Immunological Studies

…, RG Peterson, RE Handschumacher - Annals of internal …, 1971 - acpjournals.org
Forty patients with acute leukemia were treated with Intravenous L-asparaginase in doses
ranging from 10 to 1,000 international units/kg body weight per day for 2 to 20 days. Most had …

[HTML][HTML] Isolation and amino acid sequence of cyclophilin.

MW Harding, RE Handschumacher… - Journal of Biological …, 1986 - Elsevier
Cyclophilin, a specific cyclosporin A-binding protein has been purified to homogeneity from
human spleen and bovine thymus cytosol. Purification of bovine and human cyclophilin was …

Cyclophilin: distribution and variant properties in normal and neoplastic tissues.

…, MW Harding, RE Handschumacher - Journal of immunology …, 1986 - journals.aai.org
… performed with crude cytosol, including those reported in this study, may underestimate CyP
… in mitogenic responses. It is recognized that the levels of many proteins change consequent …

[HTML][HTML] The Cyclosporin A-binding Immunophilin CyP-40 and the FK506-binding Immunophilin hsp56 Bind to a Common Site on hsp90 and Exist in Independent …

…, AW Yem, MR Deibel, RE Handschumacher… - Journal of Biological …, 1995 - ASBMB
We have recently shown that hsp56, the FK506-binding immunophilin component of both
the heat shock protein (hsp90•hsp70•hsp56) heterocomplex and the untransformed …

Novel single-pass exchange of circulating uridine in rat liver

T Gasser, JD Moyer, RE Handschumacher - Science, 1981 - science.org
Evidence is presented that the liver effects an essentially complete degradation of plasma
uridine in a single pass and replaces it largely from hepatic pools of acid-soluble uridine …