Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries
…, RR Wayne, GH Mudge, RW Alexander… - … England Journal of …, 1986 - Mass Medical Soc
Acetylcholine is believed to dilate normal blood vessels by promoting the release of a
vasorelaxant substance from the endothelium (endothelium-derived relaxing factor). By contrast, if …
vasorelaxant substance from the endothelium (endothelium-derived relaxing factor). By contrast, if …
Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for …
TA Pearson, GA Mensah, RW Alexander, JL Anderson… - circulation, 2003 - Am Heart Assoc
In 1998, the American Heart Association convened Prevention Conference V to examine
strategies for the identification of high-risk patients who need primary prevention. Among the …
strategies for the identification of high-risk patients who need primary prevention. Among the …
Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.
…, CA Minieri, JD Ollerenshaw, RW Alexander - Circulation …, 1994 - Am Heart Assoc
The signaling pathways involved in the long-term metabolic effects of angiotensin II (Ang II)
in vascular smooth muscle cells are incompletely understood but include the generation of …
in vascular smooth muscle cells are incompletely understood but include the generation of …
[HTML][HTML] Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease
…, JC Cedarholm, RW Alexander - … England Journal of …, 1995 - Mass Medical Soc
Background Impaired endothelium-mediated relaxation contributes to vasospasm and
myocardial ischemia in patients with coronary artery disease. We hypothesized that cholesterol-…
myocardial ischemia in patients with coronary artery disease. We hypothesized that cholesterol-…
Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor
TJ Murphy, RW Alexander, KK Griendling, MS Runge… - Nature, 1991 - nature.com
ANGIOTENSIN II is an important effector molecule controlling blood pressure and volume in
the cardiovascular system 1 . Its importance is manifested by the efficacy of angiotensin-…
the cardiovascular system 1 . Its importance is manifested by the efficacy of angiotensin-…
Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular …
…, CA Rosen, M Ahmad, RW Alexander… - The Journal of …, 1993 - Am Soc Clin Investig
Oxidative stress and expression of the vascular cell adhesion molecule-1 (VCAM-1) on
vascular endothelial cells are early features in the pathogenesis of atherosclerosis and other …
vascular endothelial cells are early features in the pathogenesis of atherosclerosis and other …
Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase.
…, M Uematsu, RM Nerem, RW Alexander… - The Journal of …, 1992 - Am Soc Clin Investig
The constitutive endothelial cell nitric oxide synthase (NOS) importantly regulates vascular
homeostasis. To gain understanding of this enzyme, a pEF BOS cDNA library of 5 x 10(5) …
homeostasis. To gain understanding of this enzyme, a pEF BOS cDNA library of 5 x 10(5) …
Elevation of C-reactive protein in “active” coronary artery disease
BC Berk, WS Weintraub, RW Alexander - The American journal of …, 1990 - Elsevier
Unstable angina occurs most commonly in the setting of atherosclerotic coronary artery
disease (CAD), but there is little information concerning the mechanisms responsible for the …
disease (CAD), but there is little information concerning the mechanisms responsible for the …
A randomized, double-blinded, placebo-controlled multicenter trial of adenosine as an adjunct to reperfusion in the treatment of acute myocardial infarction (AMISTAD …
Objectives : The purpose of this research was to determine the effect of intravenous adenosine
on clinical outcomes and infarct size in ST-segment elevation myocardial infarction (…
on clinical outcomes and infarct size in ST-segment elevation myocardial infarction (…
Oscillatory shear stress stimulates adhesion molecule expression in cultured human endothelium
…, RM Nerem, RM Medford, RW Alexander - Circulation …, 1998 - Am Heart Assoc
Low and oscillatory shear stresses are major features of the hemodynamic environment of
sites opposite arterial flow dividers that are predisposed to atherosclerosis. Atherosclerosis is …
sites opposite arterial flow dividers that are predisposed to atherosclerosis. Atherosclerosis is …