Mammalian cells employ numerous innate cellular mechanisms to inhibit viral replication
and spread. Tetherin, also known as Bst-2 or CD317, is a recently identified, IFN-induced, …

Cellular cathepsins are required for Ebola virus infection and are believed to proteolytically
process the Ebola virus glycoprotein (GP) during entry. However, the significance of …

A tetrahydroquinoline oxocarbazate (PubChem CID 23631927) was tested as an inhibitor of
human cathepsin L (EC 3.4.22.15) and as an entry blocker of severe acute respiratory …

Ebolavirus causes severe hemorrhagic fever in humans and non-human primates. Entry of
ebolavirus is mediated by the viral glycoprotein, GP; however, the required host factors have …

Tetherin is an interferon-induced, intrinsic cellular response factor that blocks release of
numerous viruses, including Ebola virus, from infected cells. As with many viruses targeted by …

A tetrahydroquinoline oxocarbazate (PubChem CID 23631927) was tested as an inhibitor of
human cathepsin L (EC 3.4.22.15) and as an entry blocker of SARS coronavirus and Ebola …

The success of Ebola as a highly pathogenic RNA virus depends critically on its ability to
interact with host cells. Ebola's relationship with the host involves a delicate balance between …

Caenorhabditis elegans must distinguish pathogens from nutritious food sources among the
many bacteria to which it is exposed in its environment 1 . Here we show that a single …

Insulin/insulin-like growth factor signalling (IIS) is a critical regulator of an organism’s most
important biological decisions from growth, development, and metabolism to reproduction and …

The biology and behavior of adults differ substantially from those of developing animals, and
cell-specific information is critical for deciphering the biology of multicellular animals. Thus, …