Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine (“Ecstasy”) in serotonin transporter-deficient mice

…, CH Wichems, D Feltner, A Heils, R Mössner… - Molecular …, 1998 - ASPET
The sodium-dependent, high affinity serotonin [5-hydroxytryptamine (5-HT)] transporter (5-HTT)
provides the primary mechanism for inactivation of 5-HT after its release into the synaptic …

Role of serotonin in the immune system and in neuroimmune interactions

R Mössner, KP Lesch - Brain, behavior, and immunity, 1998 - Elsevier
Serotonin (5-HT) is one of the most extensively studied neurotransmitters of the central
nervous system. 5-HT is, however, also present in a variety of peripheral tissues including in …

Genetically driven variation in serotonin uptake: is there a link to affective spectrum, neurodevelopmental, and neurodegenerative disorders?

KP Lesch, R Mössner - Biological psychiatry, 1998 - Elsevier
Serotonin (5-HT) is an important regulator of morphogenetic activities during early central
nervous system development, including cell proliferation, migration, and differentiation. The 5-…

Consensus paper of the WFSBP Task Force on Biological Markers: biological markers in depression

R Mössner, O Mikova, E Koutsilieri… - The world journal of …, 2007 - Taylor & Francis
Biological markers for depression are of great interest to aid in elucidating the causes of
major depression. We assess currently available biological markers to query their validity for …

Excessive activation of serotonin (5-HT) 1B receptors disrupts the formation of sensory maps in monoamine oxidase a and 5-ht transporter knock-out mice

…, E De Maeyer, DL Murphy, R Mössner… - Journal of …, 2001 - Soc Neuroscience
Deficiency in the monoamine degradation enzyme monoamine oxidase A (MAOA) or
prenatal exposure to the monoamine uptake inhibitor cocaine alters behavior in humans and …

Serotonin transporter function is modulated by brain-derived neurotrophic factor (BDNF) but not nerve growth factor (NGF)

R Mössner, S Daniel, D Albert, A Heils… - Neurochemistry …, 2000 - Elsevier
The serotonin transporter (5-HTT) regulates serotonergic neurotransmission by determining
the magnitude and duration of serotonergic responses. We have recently described a …

Genome‐wide significant association between alcohol dependence and a variant in the ADH gene cluster

…, M Soyka, P Zill, W Maier, R Mössner… - Addiction …, 2012 - Wiley Online Library
Alcohol dependence (AD) is an important contributory factor to the global burden of disease.
The etiology of AD involves both environmental and genetic factors, and the disorder has a …

Circulating selectin-and immunoglobulin-type adhesion molecules in acute ischemic stroke

K Fassbender, R Mössner, L Motsch, U Kischka… - Stroke, 1995 - Am Heart Assoc
Background and Purpose Cellular adhesion molecules mediate adhesion between endothelial
cells and leukocytes as a precondition for extravasation of leukocytes at sites of tissue …

Association between genetic variation in a region on chromosome 11 and schizophrenia in large samples from Europe

…, S Moebus, M Alexander, R Mössner… - Molecular …, 2012 - nature.com
Recent molecular studies have implicated common alleles of small to moderate effect and
rare alleles with larger effect sizes in the genetic architecture of schizophrenia (SCZ). It is …

TDM in psychiatry and neurology: a comprehensive summary of the consensus guidelines for therapeutic drug monitoring in neuropsychopharmacology, update 2017; …

…, G Laux, T Messer, R Mössner… - The world journal of …, 2018 - Taylor & Francis
Objectives: Therapeutic drug monitoring (TDM) combines the quantification of drug concentrations
in blood, pharmacological interpretation and treatment guidance. TDM introduces a …