User profiles for Ramona F. Curpan
 | Ramona CurpanResearcher, Coriolan Dragulescu Institute of Chemistry Verified email at acad-icht.tm.edu.ro Cited by 1875 |
A crowdsourcing evaluation of the NIH chemical probes
Between 2004 and 2008, the US National Institutes of Health Molecular Libraries and
Imaging initiative pilot phase funded 10 high-throughput screening centers, resulting in the …
Imaging initiative pilot phase funded 10 high-throughput screening centers, resulting in the …
Structure− function relationships of estrogenic triphenylethylenes related to endoxifen and 4-hydroxytamoxifen
PY Maximov, CB Myers, RF Curpan… - Journal of medicinal …, 2010 - ACS Publications
Estrogens can potentially be classified into planar (class I) or nonplanar (class II) categories,
which might have biological consequences. 1,1,2-Triphenylethylene (TPE) derivatives were …
which might have biological consequences. 1,1,2-Triphenylethylene (TPE) derivatives were …
The molecular, cellular and clinical consequences of targeting the estrogen receptor following estrogen deprivation therapy
P Fan, PY Maximov, RF Curpan, B Abderrahman… - Molecular and cellular …, 2015 - Elsevier
During the past 20 years our understanding of the control of breast tumor development, growth
and survival has changed dramatically. The once long forgotten application of high dose …
and survival has changed dramatically. The once long forgotten application of high dose …
Endoxifen, 4-hydroxytamoxifen and an estrogenic derivative modulate estrogen receptor complex mediated apoptosis in breast cancer
Estrogen therapy was used to treat advanced breast cancer in postmenopausal women for
decades until the introduction of tamoxifen. Resistance to long-term estrogen deprivation (…
decades until the introduction of tamoxifen. Resistance to long-term estrogen deprivation (…
The structure-function relationship of angular estrogens and estrogen receptor alpha to initiate estrogen-induced apoptosis in breast cancer cells
High-dose synthetic estrogen therapy was the standard treatment of advanced breast cancer
for three decades until the discovery of tamoxifen. A range of substituted triphenylethylene …
for three decades until the discovery of tamoxifen. A range of substituted triphenylethylene …
Detection of intracellular granularity induction in prostate cancer cell lines by small molecules using the HyperCyt® high-throughput flow cytometry system
Prostate cancer is a leading cause of death among men due to the limited number of
treatment strategies available for advanced disease. Discovery of effective chemotherapeutics …
treatment strategies available for advanced disease. Discovery of effective chemotherapeutics …
Pharmacology and molecular mechanisms of clinically relevant estrogen estetrol and estrogen mimic BMI-135 for the treatment of endocrine-resistant breast cancer
B Abderrahman, PY Maximov, RF Curpan… - Molecular …, 2020 - ASPET
Long-term estrogen deprivation (LTED) with tamoxifen (TAM) or aromatase inhibitors leads
to endocrine-resistance, whereby physiologic levels of estrogen kill breast cancer (BC). …
to endocrine-resistance, whereby physiologic levels of estrogen kill breast cancer (BC). …
[HTML][HTML] A unifying biology of sex steroid-induced apoptosis in prostate and breast cancers
…, B Abderrahman, RF Curpan… - Endocrine-related …, 2018 - erc.bioscientifica.com
Prostate and breast cancer are the two cancers with the highest incidence in men and women,
respectively. Here, we focus on the known biology of acquired resistance to antihormone …
respectively. Here, we focus on the known biology of acquired resistance to antihormone …
Rapid induction of the unfolded protein response and apoptosis by estrogen mimic TTC-352 for the treatment of endocrine-resistant breast cancer
B Abderrahman, PY Maximov, RF Curpan… - Molecular cancer …, 2021 - AACR
Patients with long-term estrogen-deprived breast cancer, after resistance to tamoxifen or
aromatase inhibitors develops, can experience tumor regression when treated with estrogens. …
aromatase inhibitors develops, can experience tumor regression when treated with estrogens. …
Pharmacological relevance of endoxifen in a laboratory simulation of breast cancer in postmenopausal patients
…, VR Korostyshevskiy, RF Curpan… - Journal of the …, 2014 - academic.oup.com
Background Tamoxifen is metabolically activated via a CYP2D6 enzyme system to the more
potent hydroxylated derivatives 4-hydroxytamoxifen and endoxifen. This study addresses …
potent hydroxylated derivatives 4-hydroxytamoxifen and endoxifen. This study addresses …