Background and Aims Characterization of cell specific transcriptional responses to hepatotoxicants
is lost in the averages of bulk RNA-sequencing (RNA-seq). Single-cell/nuclei RNA-…

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental contaminant which
elicits hepatotoxicity through activation of the aryl hydrocarbon receptor (AhR). Male C57BL/…

We have previously shown that in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-elicited
NAFLD progression, central carbon, glutaminolysis, and serine/folate metabolism are …

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental contaminant that
induces the progression of steatosis to steatohepatitis with fibrosis in mice. Furthermore, …

The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces
hepatic steatosis mediated by the aryl hydrocarbon receptor. To further characterize TCDD-elicited …

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a potent aryl hydrocarbon receptor agonist
that elicits dose-dependent hepatic fat accumulation and inflammation that can progress to …

Aryl hydrocarbon receptor (AhR) activation is reported to alter the hepatic expression of
circadian clock regulators, however the impact on clock-controlled metabolism has not been …

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dose-dependently induces the development of
hepatic fat accumulation and inflammation with fibrosis in mice initially in the portal region. …

Persistent aryl hydrocarbon receptor (AhR) agonists elicit dose-dependent hepatic lipid
accumulation, oxidative stress, inflammation, and fibrosis in mice. Iron (Fe) promotes AhR-…

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental pollutant that
activates the aryl hydrocarbon receptor (AhR) resulting in altered gene expression. In vivo, in …