Nicotinic acid adenine dinucleotide phosphate (NAADP) is a molecule capable of initiating
the release of intracellular Ca 2+ required for many essential cellular processes. Recent …

1. Calcium‐release channels of sheep cardiac junctional sarcoplasmic reticulum were
incorporated into planar phospholipid bilayers. Single‐channel current fluctuations were recorded …

Mutations in either polycystin-1 (PC1 or PKD1) or polycystin-2 (PC2, PKD2 or TRPP1) cause
autosomal-dominant polycystic kidney disease (ADPKD) through unknown mechanisms. …

1. The gating and conduction properties of single calcium‐release channels of sheep
isolated cardiac junctional sarcoplasmic reticulum membranes incorporated into planar …

We have used tryptic digestion to determine whether Ca 2+ can regulate cardiac ryanodine
receptor (RyR) channel gating from within the lumen of the sarcoplasmic reticulum (SR) or …

Membranes in cells have defined distributions of lipids in each leaflet, controlled by lipid
scramblases and flip/floppases. However, for some intracellular membranes such as the …

NAADP potently triggers Ca 2+ release from acidic lysosomal and endolysosomal Ca 2+
stores. Human two-pore channels (TPC1 and TPC2), which are located on these stores, are …

Intracellular Ca 2+ release through ryanodine receptor (RyR) and inositol trisphosphate
receptor (IP 3 R) channels is supported by a complex network of additional proteins that are …

… In this article, Rebecca Sitsapesan, Stephen McGarry and Alan Williams review the
mechanisms involved in cyclic ADP-ribose (cADPR)-induced Ca 2+ release and discuss the …

1. Introduction 622. Channel structure 632.1 Isoforms, primary structure and topology of Ca2+-release
channels 632.2 Identification of ligand binding sites within the primary sequence …