Acute stress suppresses pain by activating brain pathways that engage opioid or non-opioid
mechanisms. Here we show that an opioid-independent form of this phenomenon, termed …

BACKGROUND: The endocannabinoid anandamide may be involved in the regulation of
emotional reactivity. In particular, it has been shown that pharmacological inhibition of the …

The endocannabinoids anandamide and 2-arachidonoyglycerol (2-AG) may contribute to
the regulation of mood and emotion. In this study, we investigated the impact of the …

Activation of group I metabotropic glutamate (mGlu) receptors drives the endocannabinoid
system to cause both short- and long-term changes of synaptic strength in the striatum, …

BACKGROUND: CB 1 cannabinoid receptors in the brain are known to participate in the
regulation of reward-based behaviors. However, the contribution of each of the …

… Mangieri, 2 … Find articles by Mangieri, R. in: JCI | PubMed | Google Scholar | …
Preclinical: ARO, KBG, RA Mangieri, RA Morrisett, AJR, and MFL conceived and performed …

The endocannabinoid system modulates neurotransmission at inhibitory and excitatory
synapses in brain regions relevant to the regulation of pain, emotion, motivation, and cognition. …

The endocannabinoid system may serve important functions in the central and peripheral
regulation of pain. In the present study, we investigated the effects of the endocannabinoid …

Cannabinoids are well known modulators of mood and emotional behavior. Current research
supports a role for endocannabinoid signaling in the treatment of depression. Changes in …

Background Two parallel and interacting processes are said to underlie animal behavior,
whereby learning and performance of a behavior is at first via conscious and deliberate (goal-…