The functional role of heteromers of G-protein-coupled receptors is a matter of debate. In the
present study, we demonstrate that heteromerization of adenosine A 1 receptors (A 1 Rs) …

ATP is released in an activity-dependent manner from different cell types in the brain,
fulfilling different roles as a neurotransmitter, neuromodulator, in astrocyte-to-neuron …

ATP is released in a vesicular manner from nerve terminals mainly at higher stimulation
frequencies. There is a robust expression of ATP (P2) receptors in the brain, but their role is …

The anti‐Parkinsonian effect of glutamate metabotropic group 5 (mGluR5) and adenosine A
2A receptor antagonists is believed to result from their ability to postsynaptically control the …

Adenosine neuromodulation depends on a balanced activation of inhibitory A 1 (A 1 R) and
facilitatory A 2A receptors (A 2A R). Both A 1 R and A 2A R modulate hippocampal …

Different presynaptic neuromodulation systems have been explored as possible targets to
manage neurodegenerative diseases. However, most studies used young adult animals …

INTRODUCTION During development, brain circuits go through phases of synapse formation,
stabilization, or elimination. γ-aminobutyric acid–mediated (GABAergic) synapse formation …

Adenosine and dopamine are two important modulators of glutamatergic neurotransmission
in the striatum. However, conflicting reports exist about the role of adenosine and adenosine …

Despite the profound effect of cannabinoids on motor function, and their therapeutic potential
in Parkinson's and Huntington's diseases, the cellular and subcellular distributions of …

Despite the profound effect of cannabinoids on motor function, and their therapeutic potential
in Parkinson's and Huntington's diseases, the cellular and subcellular distributions of …