Double-antibody immunoprecipitation procedures with antisera to endorphins and to
corticotropin (ACTH) were used to study the biosynthesis of these peptides in a mouse pituitary …

The prevalence, diversity, and multiplicity of functions of pep tides in the nervous system are
well known. However, we are only now approaching the point at which our knowledge …

The morphogenesis of dendritic spines, the major sites of excitatory synaptic transmission in
the brain, is important in synaptic development and plasticity. We have identified an ephrinB-…

Spine function requires precise control of the actin cytoskeleton. Kalirin-7, a GDP/GTP exchange
factor for Rac1, interacts with PDZ proteins such as PSD-95, colocalizing with PSD-95 …

Copper active sites play a major role in enzymatic activation of dioxygen. We trapped the
copper-dioxygen complex in the enzyme peptidylglycine-alphahydroxylating monooxygenase (…

Many neuropeptides and peptide hormones require amidation at the carboxyl terminus for
activity. Peptidylglycine α-amidating monooxygenase (PAM) catalyzes the amidation of these …

Peptide α‐amidation is a widespread, often essential posttranslational modification shared
by many bioactive peptides and accomplished by the products of a single gene encoding a …

An enzymatic activity capable of producing an alpha-amidated peptide product from its
glycine-extended precursor has been identified in secretory granules of rat anterior, intermediate, …

Graded, reversible suppression of neuronal excitability represents a logical goal of therapy
for epilepsy and intractable pain. To achieve such suppression, we have developed the …

Two subtilisin-like endoproteases called PC1 and PC2 are distributed in a tissue-specific
manner in the pituitary and in the brain. AtT-20 cells and corticotropes of the anterior pituitary …