Human glutathione S-transferase P1 polymorphisms: relationship to lung tissue enzyme activity and population frequency distribution.
MA Watson, RK Stewart, GB Smith, TE Massey… - …, 1998 - academic.oup.com
The association between glutathione S-transferase (GST) activity as measured by 1-chloro-2,4-dinitrobenzene
(CDNB) conjugation and genotype at exon 5 and exon 6 of the human …
(CDNB) conjugation and genotype at exon 5 and exon 6 of the human …
Biochemical and Molecular Aspects of Mammalian Susceptibility to Aflatoxin B1 Carcinogenicity
TE Massey, RK Stewart… - Proceedings of the …, 1995 - journals.sagepub.com
Aflatoxin B 1 (AFB 1 ) is a fungal toxin that has been implicated as a causative agent in human
hepatic and extrahepatic carcinogenesis. In this review, the mechanisms involved in AFB …
hepatic and extrahepatic carcinogenesis. In this review, the mechanisms involved in AFB …
ATP-dependent transport of aflatoxin B1 and its glutathione conjugates by the product of the multidrug resistance protein (MRP) gene
DW Loe, RK Stewart, TE Massey, RG Deeley… - Molecular …, 1997 - ASPET
Glutathione-S-transferase-catalyzed conjugation of glutathione (GSH) to aflatoxin B 1 -8,9-epoxide
plays an important role in preventing binding of this ultimate carcinogen to target …
plays an important role in preventing binding of this ultimate carcinogen to target …
Biotransformation of aflatoxin B1 in human lung
PJ Donnelly, RK Stewart, SL Ali, AA Conlan… - …, 1996 - academic.oup.com
In addition to being a potent hepatocarcinogen, aflatoxin B 1 (AFB 1 ) is a pulmonary
carcinogen in experimental animals, and epidemiological studies have shown an association …
carcinogen in experimental animals, and epidemiological studies have shown an association …
Disposition of a low dose of bisphenol A in male and female cynomolgus monkeys
H Kurebayashi, R Harada, RK Stewart… - Toxicological …, 2002 - academic.oup.com
Bisphenol A (BPA) is a weak estrogenic compound mass-produced with potential human
exposure. Following a single oral or intravenous (iv) dose of 100 μg/kg [ring- 14 C(U)] …
exposure. Following a single oral or intravenous (iv) dose of 100 μg/kg [ring- 14 C(U)] …
GlutathioneS-Transferase-Catalyzed Conjugation of Bioactivated Aflatoxin B1in Rabbit Lung and Liver
RK Stewart, CJ Serabjit-Singh, TE Massey - Toxicology and applied …, 1996 - Elsevier
Aflatoxin B 1 (AFB 1 ) requires bioactivation to AFB 1 -8,9-epoxide for carcinogenicity, and
glutathioneS-transferase (GST)-catalyzed conjugation of activated AFB 1 with glutathione (…
glutathioneS-transferase (GST)-catalyzed conjugation of activated AFB 1 with glutathione (…
Biotransformation of aflatoxin B1 in rabbit lung and liver microsomes
JM Daniels, L Liu, RK Stewart, TE Massey - Carcinogenesis, 1990 - academic.oup.com
Aflatoxin B 1 (AFB 1 ) is a potent hepatotoxic and hepato carcinogenic mycotoxin that
requires bioactivation to AFB 1 -2,3-oxide for activity. In addition to epoxidation, microsomal …
requires bioactivation to AFB 1 -2,3-oxide for activity. In addition to epoxidation, microsomal …
The intravascular persistence and methemoglobin formation of Hemolink™(hemoglobin raffimer) in dogs
…, LT Wong, R Sandhu, RK Stewart… - Artificial cells, blood …, 2003 - Taylor & Francis
Hemoglobin raffimer (HEMOLINK™, Hemosol Inc, Mississauga, Canada) is an o‐raffinose
cross‐linked, purified human hemoglobin‐based oxygen therapeutic that is currently being …
cross‐linked, purified human hemoglobin‐based oxygen therapeutic that is currently being …
Modulation of aflatoxin B1 biotransformation by β-naphthoflavone in isolated rabbit lung cells
SH Im, MW Bolt, RK Stewart, TE Massey - Archives of toxicology, 1996 - Springer
The cytotoxic and carcinogenic mycotoxin aflatoxin (AF) B 1 (AFB 1 ) is biotransformed by
the cytochrome P450 monooxygenases (CYP) to a number of relatively nontoxic metabolites, …
the cytochrome P450 monooxygenases (CYP) to a number of relatively nontoxic metabolites, …
In vitro prostaglandin H synthase- and monooxygenase-mediated binding of aflatoxin B1 to DNA in guinea-pig tissue microsomes
L Liu, JM Daniels, RK Stewart, TE Massey - Carcinogenesis, 1990 - academic.oup.com
In order to study the mechanism of cancer production by aflatoxin B 1 (AFB 1 ) in extrahepatic
tissues which have relatively low cytochrome P450 monooxygenase (P450) activity, we …
tissues which have relatively low cytochrome P450 monooxygenase (P450) activity, we …