Trophoblast invasion of the uterine extracellular matrix, a critical process of human implantation
and essential for fetal development, is a striking example of controlled invasiveness. To …

Distal hereditary motor neuropathy (dHMN) or distal spinal muscular atrophy (OMIM #182960)
is a heterogeneous group of disorders characterized by an almost exclusive degeneration …

Mitochondrial Ca 2+ uptake is crucial for the regulation of the rate of oxidative phosphorylation
1 , the modulation of spatio-temporal cytosolic Ca 2+ signals 2 , 3 , 4 and apoptosis 5 . …

Causes of autosomal-recessive intellectual disability (ID) have, until very recently, been
under researched because of the high degree of genetic heterogeneity. However, now that …

Activation of endothelial cells by lipid oxidation products is a key event in the initiation and
progression of the atherosclerotic lesion. Minimally modified low-density lipoprotein (MM-LDL…

Ion selectivity is a defining feature of a given ion channel and is considered immutable. Here
we show that ion selectivity of the lysosomal ion channel TPC2, which is hotly debated (…

Mitochondria are ancient endosymbiotic guests that joined the cells in the evolution of
complex life. While the unique ability of mitochondria to produce adenosine triphosphate (ATP) …

Although the endocannabinoid anandamide is frequently described to act predominantly in
the cardiovascular system, the molecular mechanisms of its signaling remained unclear. In …

Mitochondria have been found to sequester and release Ca 2+ during cell stimulation with
inositol 1,4,5-triphosphate-generating agonists, thereby generating subplasmalemmal …

Adipose triglyceride lipase (ATGL) catalyzes the first step in the hydrolysis of triacylglycerol (TG)
generating diacylglycerol and free fatty acids. The enzyme requires the activator protein …