Reversal of integration and DNA splicing mediated by integrase of human immunodeficiency virus

SA Chow, KA Vincent, V Ellison, PO Brown - Science, 1992 - science.org
In retroviral integration, the viral integration protein (integrase) mediates a concerted DNA
cleavage-ligation reaction in which the target DNA is cleaved and the resulting 5′ ends of …

Inhibitors of HIV-1 replication that inhibit HIV integrase.

…, S Abdel-Malek, Q Jia, SA Chow - Proceedings of the …, 1996 - National Acad Sciences
HIV-1 replication depends on the viral enzyme integrase that mediates integration of a DNA
copy of the virus into the host cell genome. This enzyme represents a novel target to which …

Dicaffeoylquinic acid inhibitors of human immunodeficiency virus integrase: inhibition of the core catalytic domain of human immunodeficiency virus integrase.

…, M Cordeiro, S Abdel-Malek, Q Jia, SA Chow… - Molecular …, 1996 - ASPET
Integration of a cDNA copy of the human immunodeficiency virus (HIV) genome is mediated
by an HIV-1-encoded enzyme, integrase (IN), and is required for productive infection of CD4…

An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors

…, D Ganem, JL DeRisi, SA Chow… - Proceedings of the …, 2007 - National Acad Sciences
We recently reported identification of a previously undescribed gammaretrovirus genome,
xenotropic murine leukemia virus-related virus (XMRV), in prostate cancer tissue from patients …

Human immunodeficiency virus type 1 incorporated with fusion proteins consisting of integrase and the designed polydactyl zinc finger protein E2C can bias …

…, Z Dong, TA Wilkinson, CF Barbas III, SA Chow - Journal of …, 2006 - Am Soc Microbiol
In vitro studies using fusion proteins consisting of human immunodeficiency virus type 1
integrase (IN) and a synthetic polydactyl zinc finger protein E2C, a sequence-specific DNA-…

Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein E2C direct integration of viral DNA into …

…, K Zhu, DJ Segal, CF Barbas III, SA Chow - Journal of virology, 2004 - Am Soc Microbiol
… We thank Michelle Holmes-Son and other members of the Chow laboratory for helpful
discussions, Luke Deltredici for graphic support, and Michael Carey for comments on and critical …

Requirement for integrase during reverse transcription of human immunodeficiency virus type 1 and the effect of cysteine mutations of integrase on its interactions with …

K Zhu, C Dobard, SA Chow - Journal of virology, 2004 - Am Soc Microbiol
Retroviral integrase catalyzes the essential step of integrating a double-stranded DNA copy
of the viral genome into a host cell chromosome. Mutational studies have revealed that …

Integrase interacts with nucleoporin NUP153 to mediate the nuclear import of human immunodeficiency virus type 1

…, S Prakobwanakit, S Mosessian, SA Chow - Journal of …, 2009 - Am Soc Microbiol
The ability to traverse an intact nuclear envelope and productively infect nondividing cells is
a salient feature of human immunodeficiency virus type 1 (HIV-1) and other lentiviruses, but …

[PDF][PDF] Dynamics of HSPC repopulation in nonhuman primates revealed by a decade-long clonal-tracking study

…, ME Metzger, AC Bonifacino, M Sehl, SA Chow… - Cell stem cell, 2014 - cell.com
In mice, clonal tracking of hematopoietic stem cells (HSCs) has revealed variations in
repopulation characteristics. However, it is unclear whether similar properties apply in primates. …

Irreversible inhibition of human immunodeficiency virus type 1 integrase by dicaffeoylquinic acids

…, J Atienza, WE Robinson Jr, SA Chow - Journal of …, 1999 - Am Soc Microbiol
Human immunodeficiency virus type 1 (HIV-1) and other retroviruses require integration of a
double-stranded DNA copy of the RNA genome into the host cell chromosome for …