Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series
…, CL Etienne, PY Law, SC Roerig… - Proceedings of the …, 2005 - National Acad Sciences
Given the mounting evidence for involvement of δ opioid receptors in the tolerance and
physical dependence of μ opioid receptor agonists, we have investigated the possible physical …
physical dependence of μ opioid receptor agonists, we have investigated the possible physical …
Absence of conditioned place preference or reinstatement with bivalent ligands containing mu-opioid receptor agonist and delta-opioid receptor antagonist …
…, DJ Daniels, PS Portoghese, SC Roerig - European journal of …, 2007 - Elsevier
… Although most conditioned place preference studies use ip or sc administration, iv
administration was employed for all experiments to conserve the limited supply of bivalent ligands. …
administration was employed for all experiments to conserve the limited supply of bivalent ligands. …
N-naphthoyl-β-naltrexamine (NNTA), a highly selective and potent activator of μ/κ-opioid heteromers
…, AE Kalyuzhny, SC Roerig… - Proceedings of the …, 2011 - National Acad Sciences
Numerous G protein-coupled receptors (GPCRs) have been shown to form heteromeric
receptors in cell-based assays. Among the many heteromers reported in the opioid receptor …
receptors in cell-based assays. Among the many heteromers reported in the opioid receptor …
Identification of three separate guanine nucleotide-binding proteins that interact with the delta-opioid receptor in NG108-15 neuroblastoma x glioma hybrid cells.
SC Roerig, HH Loh, PY Law - Molecular Pharmacology, 1992 - ASPET
Five separate guanine nucleotide-binding proteins (G proteins) were immunologically
identified in membranes from neuroblastoma x glioma NG108-15 hybrid cells. These alpha …
identified in membranes from neuroblastoma x glioma NG108-15 hybrid cells. These alpha …
Role of 5-hydroxytryptamine3 (5-HT3) antagonists in the prevention of emesis caused by anticancer therapy
F Karim, SC Roerig, D Saphier - Biochemical pharmacology, 1996 - Elsevier
Most anticancer drugs are cytotoxic and produce various side-effects, among which nausea
and vomiting are almost ubiquitous and usually extremely distressing to the patient. Cancer …
and vomiting are almost ubiquitous and usually extremely distressing to the patient. Cancer …
Spinal interactions between opioid and noradrenergic agonists in mice: multiplicativity involves delta and alpha-2 receptors.
SC Roerig, S Lei, K Kitto, JK Hylden… - Journal of Pharmacology …, 1992 - ASPET
The nature of the interaction between spinally administered opioid and alpha-2 agonists was
investigated using the substance P behavioral test in mice. Morphine and agonists which …
investigated using the substance P behavioral test in mice. Morphine and agonists which …
Analgesic potencies of morphine 3‐and 6‐sulfates after intracerebroventricular administration in mice: Relationship to structural characteristics defined by mass …
CE Brown, SC Roerig, VT Burger… - Journal of …, 1985 - Wiley Online Library
Morphine 3‐sulfate, which carries a polar, acidic group at the 3‐position much like morphine,
does not differ greatly in analgesic potency from morphine following intracerebroventricular …
does not differ greatly in analgesic potency from morphine following intracerebroventricular …
Inhibition of neural and neuroendocrine activity by α-interferon: neuroendocrine, electrophysiological, and biochemical studies in the rat
D Saphier, SC Roerig, C Ito, WR Vlasak… - Brain, Behavior, and …, 1994 - Elsevier
In our earlier studies we have demonstrated that recombinant human interferon-α2A (rHu-IFN-α2A)
inhibits hypothalamo-pituitary-adrenocortical (HPA) secretion following both …
inhibits hypothalamo-pituitary-adrenocortical (HPA) secretion following both …
[PDF][PDF] Multiplicative interaction between intrathecally and intracerebroventricularly administered mu opioid agonists but limited interactions between delta and kappa …
SC Roerig, JM Fujimoto - Journal of Pharmacology and Experimental …, 1989 - Citeseer
Simultaneous action of morphine on supraspinal and spinal sites produces a multiplicative
interaction for antinociception which may be important for the analgesia produced by …
interaction for antinociception which may be important for the analgesia produced by …
Cardiac excitation-contraction coupling in the portal hypertensive rat
…, JM O'Donnell, SC Roerig… - American Journal …, 2000 - journals.physiology.org
Basal contractility and responses to β-adrenoceptor activation are compromised in hearts
from rats with chronic portal vein stenosis. Here we report the effect of partial ligation of the …
from rats with chronic portal vein stenosis. Here we report the effect of partial ligation of the …