To date, studies suggest that biological signaling by nitric oxide (NO) is primarily mediated by
cGMP, which is synthesized by NO-activated guanylyl cyclases and broken down by cyclic …

… Francis, unpublished results). For these two PDEs, order of potency for these cations is Zn2+
>>Mg . 2+ Subsequent reports demonstrate that catalytic activity of recombinant PDE4A is …

The superfamily of cyclic nucleotide (cN) phosphodiesterases (PDEs) is comprised of 11
families of enzymes. PDEs break down cAMP and/or cGMP and are major determinants of …

The advent of the medication, sildenafil, 1 for treatment of male impotence has attracted
widespread attention. This agent potently inhibits a cGMP-binding cGMP-specific …

… speeds occurs smoothly, as is shown in Figu re 2b, so that the actual reflection of upward-propagating
gravity waves by thermospheric sound speed gradients is quite weak [Francis, …

… Francis SH, Corbin 10. Progress in understanding the mechanism and function of cGMP-dependent
protein kinase. In Advance in Pharmacology, Cyclic GMP: Synthesis, Metabolism …

Sildenafil is a selective inhibitor of phosphodiesterase type 5 (PDE5), which has been shown
to be a clinically effective treatment for erectile dysfunction. Its action results from increased …

The clinical properties (efficacy and safety profile) of a medicine are related not only to its
mode of action, but also to its selectivity for its target (usually a receptor or enzyme) and are …

The theoretical and observational evidence concerning the global propagation of atmospheric
gravity waves is reviewed, with special emphasis on waves generated in the auroral …

Intracellular cAMP and cGMP levels are increased in response to a variety of hormonal and
chemical stimuli; these nucleotides play key roles as second messenger signals in …